General pharmacology Flashcards

0
Q

Memantine

A
  • it is a NMDA receptor antagonists (NMDA receptor= glutaminergic excitatory receptor)
  • it poses neuroprotective role as over-active neurones can be damaging
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1
Q

Donepezil
Galantamine
Rivastigmine

A
  • these are cholinesterase inhibitors used in improving Alzheimer’s symptoms
  • to compensate the degenerative neurones, we increase the AcH level in synapses = increase strengths in other neurones
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2
Q

Semagacestat

A
  • potential treatment for dementia by reducing beta-amyloid 42 protein production
  • but actually could have a worse cognitive outcome due to affecting the normal pathway
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3
Q

Clioquinol

A
  • Cu/Zn chelator that promotes faster clearance of beta-amyloid plaques
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4
Q

Statin (in neuropathological role)

A
  • causes lipid partitioning so relieve oxidative stress and causes clearance of aggregated beta-amyloids
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5
Q

Lithium

A
  • can inhibit gene GSK3 beta which is the main drive of hyperphsophylating tau protein
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6
Q

Paclitaxel

A
  • microtubule modifiers
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7
Q

Rember

TauRx

A
  • tau protein aggregation inhibitors
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