General pharmacology Flashcards
0
Q
Memantine
A
- it is a NMDA receptor antagonists (NMDA receptor= glutaminergic excitatory receptor)
- it poses neuroprotective role as over-active neurones can be damaging
1
Q
Donepezil
Galantamine
Rivastigmine
A
- these are cholinesterase inhibitors used in improving Alzheimer’s symptoms
- to compensate the degenerative neurones, we increase the AcH level in synapses = increase strengths in other neurones
2
Q
Semagacestat
A
- potential treatment for dementia by reducing beta-amyloid 42 protein production
- but actually could have a worse cognitive outcome due to affecting the normal pathway
3
Q
Clioquinol
A
- Cu/Zn chelator that promotes faster clearance of beta-amyloid plaques
4
Q
Statin (in neuropathological role)
A
- causes lipid partitioning so relieve oxidative stress and causes clearance of aggregated beta-amyloids
5
Q
Lithium
A
- can inhibit gene GSK3 beta which is the main drive of hyperphsophylating tau protein
6
Q
Paclitaxel
A
- microtubule modifiers
7
Q
Rember
TauRx
A
- tau protein aggregation inhibitors