General pharmacology

Question 0

Memantine

Answer 0

• it is a NMDA receptor antagonists (NMDA receptor= glutaminergic excitatory receptor)
• it poses neuroprotective role as over-active neurones can be damaging

Question 1

Donepezil
Galantamine
Rivastigmine

Answer 1

• these are cholinesterase inhibitors used in improving Alzheimer’s symptoms
• to compensate the degenerative neurones, we increase the AcH level in synapses = increase strengths in other neurones

Question 2

Semagacestat

Answer 2

• potential treatment for dementia by reducing beta-amyloid 42 protein production
• but actually could have a worse cognitive outcome due to affecting the normal pathway

Question 3

Clioquinol

Answer 3

• Cu/Zn chelator that promotes faster clearance of beta-amyloid plaques

Question 4

Statin (in neuropathological role)

Answer 4

• causes lipid partitioning so relieve oxidative stress and causes clearance of aggregated beta-amyloids

Question 5

Lithium

Answer 5

• can inhibit gene GSK3 beta which is the main drive of hyperphsophylating tau protein

Question 6

Paclitaxel

Answer 6

• microtubule modifiers

Question 7

Rember

TauRx

Answer 7

• tau protein aggregation inhibitors