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Pharma > General Pharma > Flashcards

General Pharma Flashcards

1
Q

The first pharma company to mass-produce insulin, penicillin, the Salk polio vaccine was…

A

Eli Lilly, founded in 1876

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2
Q

The first pharma company to produce human insulin (Humulin, Humalog, Basaglar (US)) using recombinant DNA tech was…

A

Eli Lilly

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3
Q

Humulin (marketed in 1982, E. coli) and insulin lispro (marketed by Eli Lilly & Co. as Humalog, approved in USA 1996) are examples of…

A

Human insulin produced using recombinant DNA

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4
Q

Which is faster-acting, Humulin or Humalog?

A

Humalog, AKA insulin lispro, named after the reversal of the penultimate lysine and proline residues on the C-terminal end of the B-chain

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5
Q

Insulin lispro is a fast-acting insulin analog marketed by Eli Lilly as…

A

Humalog (think analog Humalog)

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6
Q

The world’s largest manufacturer and distributor of psychiatric meds is…

A

Eli Lilly

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7
Q

Fluoxetine (discovered 1972, approved 1986) is marketed by the trade names…

A

Prozac and Sarafem (among others)

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8
Q

In what antidepressant class does Prozac (fluoxetine) belong to?

A

SSRI

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9
Q

Fluoxetine (Prozac) was opened up to generic manufacturing in what year?

A

2001

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10
Q

When did Eli Lilly’s patent for Prozac expire?

A

2001

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11
Q

What four antidepressants does the FAA permit pilots to take?

A

Fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa), escitalopram (Lexapro)

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12
Q

The SSRI sertraline (FDA approved in 1991) is marketed by Pfizer as…

A

Zoloft

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13
Q

Zoloft (Pfizer, FDA approved in 1991) has the chemical name…

A

sertraline

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14
Q

The SSRI citalopram (Denmark 1989; USA 1998; major depression) has the market name…

A

Celexa and Cipramil (among others)

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15
Q

Celexa (marketed in Denmark by Lundbeck in 1989, USA in 1998) has the chemical name…

A

Citalopram

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16
Q

The patent for citalopram (Celexa, Cipramil) expired in…

A

2003

17
Q

Which company manufactures and markets citalopram in the USA?

A

Forest Labs (July 2014: acquired by Actavis, which in June 2015 became Allergan, Plc)

18
Q

Allergan, Plc was formed in February–June, 2015 when which company changed its name?

A

Actavis, Plc

19
Q

Allergan’s American Generics division is called…

A

Actavis (Note the lack of “Plc”)

20
Q

Escitalopram (the left-enantiomer of citalopram) has which two brand names?

A

Lexapro, Cipralex (think: Cipramil, but lex left)

21
Q

What is the chemical name for the (S)-stereoisomer (left-enantiomer) of citalopram, an SSRI marketed by Lundbeck in Denmark in 1989, USA in 1998?

A

Escitalopram

22
Q

Name some current or former Klick clients among the top 20.

A

Ranked by total global revenue:

  1. Pfizer (USA)
  2. Johnson & Johnson (USA)
  3. Hoffman–La Roche (CHE)
  4. Novartis (CHE)
  5. Sanofi-Aventis (France)
  6. Merck & Co. (USA)
  7. Bristol-Myers Squibb (USA)
  8. Takeda (JPN)
23
Q

The Belgian-headquartered pharma company UCB stands for…

A

Union Chimique Belge S.A. (Société anonyme)

24
Q

Union Chimique Belge S.A., headquartered in Brussels, focuses on R&D for drugs for which three diseases?

A

Epilepsy, Parkinson’s, Crohn’s

25
Q

UCB, founded in 1928, discovered what nootropic in the 1970s?

A

Piracetam, marketed as Nootropil

26
Q

Paxil’s generic name is…

A

paroxetine (not to be confused by fluoroxetine = Prozac or Sarafem)

27
Q

Paroxetine is an SSRI better known as…

A

Paxil

28
Q

Marketing of the SSRI _____ began in 1992 by SmithKline Beecham, known since 2000 as GlaxoSmithKline.

A

Paxil (paroxetine)

29
Q

Paxil (paroxetine) was first marketed in 1992 by _____, known since 2000 as _____.

A

SmithKline Beecham, now GlaxoSmithKline

30
Q

The patent for Paxil (paroxetine) expired in _____.

A

2003

31
Q

AbbVie originated in 2013 as a spinoff of ____

A

Abbott Laboratories

32
Q

In 2013, Illinois-based Abbott Laboratories split off research-based drugs into the company ____

A

AbbVie

33
Q

AbbVie’s flagship drug is the whole-antibody drug adalimumab, marketed as ____

A

Humira

34
Q

Humira’s generic name is ____

A

Adalimumab

35
Q

In what year did the US patent for Humira (adalimumab) expire?

A

2016

36
Q

Humira (adalimumab) is a treatment for autoimmune diseases. Name three.

A 
Arthritis: rheumatoid, psoriatic, juvenile idiopathic
Ankylosing spondylitis
Crohn's disease
Ulcerative colitis
Chronic psoriasis

Pharma (4 decks)

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