General Neoplasia Flashcards
Nodules of cancer frequently display central necrosis (umbilication). Causes of tumor cell death in situ include 1. apoptosis 2. ischemia 3. paucity of nutrients 4. vulnerability to host defenses
Causes of tumor cell death in situ include 1. apoptosis 2. inadequate blood supply & ischemia 3. a paucity of nutrients 4. vulnerability to specific and non-specifc host defenses
_____ is a tumor marker for
- adenocarcinomas of the colon
- malignant tumors of the pancreas, lung, and ovary
CEA is a tumor marker for
- adenocarcinomas of the colon
- malignant tumors of the pancreas, lung, and ovary
Neuroendocrine tumors can be identified by their content of _____.
Neuroendocrine tumors can be identified by their content of chromogranins.
_____ is expressed by hepatocellular and yolk sac tumors.
AFP is expressed by hepatocellular and yolk sac tumors.
Chorionic gonadotropin is secreted by ___carcinomas.
Chorionic gonadotropin is secreted by choriocarcinomas.
Tumor marker for soft tissue sarcomas. An intermediate filament.
Vimentin
Tumor marker for soft tissue sarcomas. An intermediate filament.
Malignant lymphomas are generally positive for _____.
Malignant lymphomas are generally positive for leukocyte common antigen (LCA).
Hypermethylation is an example of _____ modification.
Hypermethylation of many _____ _____ and _____ _____ genes has been demonstrated in human tumors, including the p53 pathway.
Unlike genetic changes in cancer, epigenetic changes are reversible.
Hypermethylation is an example of epigenetic modification.
Hypermethylation of many tumor supressor and DNA repair genes has been demonstrated in human tumors, including the p53 pathway.
Unlike genetic changes in cancer, epigenetic changes are reversible.
_____ are benign tumors composed of tissues from all three primary germ layers: ectoderm, mesoderm, endoderm.
They are most common in the ovary, testis, and extragonadal sites.
They contain a variety of structures – skin, neurons, glial cells, cartilage, glandular epithelium.
Teratomas are benign tumors composed of tissues from all three primary germ layers: ectoderm, mesoderm, endoderm.
They are most common in the ovary, testis, and extragonadal sites.
They contain a variety of structures – skin, neurons, glial cells, cartilage, glandular epithelium.
_____ are malignant tumors that harbor embryonal carcinoma stem cells.
Teratocarcinomas are malignant tumors that harbor embryonal carcinoma stem cells.
Localized, disordered differentiation during embryonic development results in a _____, a disorganized caricature of normal tissue components such as cartilage, blood vessels, lymphoid tissue, ducts or bronchi.
Localized, disordered differentiation during embryonic development results in a hamartoma, a disorganized caricature of normal tissue components such as cartilage, blood vessels, lymphoid tissue, ducts or bronchi.
Cancer Epidemiology - what country is associated with each cancer?
Stomach cancer: _____
Colorectal cancer: _____
Prostate cancer: _____
Cancer Epidemiology
Stomach cancer: Japan
Colorectal cancer: United States
Prostate cancer: American blacks
Disease: _____ _____
- autosomal recessive
- increased sensitivity to UV radiation
- pyrimidine dimers
- high incidence of skin cancer
- germline mutations in gene encoding nucleotide excision repair enzyme
Xeroderma Pigmentosum
- autosomal recessive
- increased sensitivity to UV radiation
- pyrimidine dimers
- high incidence of skin cancer
- germline mutations in gene encoding nucleotide excision repair enzyme
Li-Fraumeni syndrome
Germline mutations of _____ lead to inherited predisposition to develop cancers in many organs. The gene functions in transcriptional regulation.
Li-Fraumeni syndrome
Germline mutations of p53 lead to inherited predisposition to develop cancers in many organs. The gene functions in transcriptional regulation.
_____ _____
- mutation in ATM gene, which codes for a nuclear phosphoprotein involved in cell cycle regulation and DNA repair
- cerebellar degeneration
- immunologic abnormalities
- predisposition to cancer
Ataxia telangiectasia
- mutation in ATM gene, which codes for a nuclear phosphoprotein involved in cell cycle regulation and DNA repair
- cerebellar degeneration
- immunologic abnormalities
- predisposition to cancer
Most common causes of death from cancer in women:
- _____
- _____
Most common causes of death from cancer in women:
- Lung cancer
- Breast cancer
_____-_____ anemia is common in cancers that bleed into the GI tract, such as colorectal cancer.
Iron-deficiency anemia is common in cancers that bleed into the GI tract, such as colorectal cancer.
c-abl protooncogene on chromosome 9 t(9,22) –> _____ _____ _____
c-abl protooncogene on chromosome 9 t(9,22) –> chronic myelogenous leukemia
Neuroblastomas
small cell carcinoma of the lung
Wilms tumor
hepatoblastoma
are all associated with gene amplification of _____-family protooncogenes
Neuroblastomas
small cell carcinoma of the lung
Wilms tumor
hepatoblastoma
are all associated with gene amplification of myc-family protooncogenes
Breast cancer and Ovarian cancer are associated with gene amplification of the Erb2 or ___/___ protooncogene
Breast cancer and Ovarian cancer are associated with gene amplification of the Erb2 or HER2/neu protooncogene
C-sis protooncogene encodes _____
–associated with sarcomas and glioblastomas when it is constitutively expressed.
C-sis protooncogene encodes PDGF
–associated with sarcomas and glioblastomas when it is constitutively expressed.
_-___ encodes a receptor for HGF.
Point mutations in _-___ are involved in papillary renal cancers.
C-met encodes a receptor for HGF.
Point mutations in c-met are involved in papillary renal cancers.
Germline point mutations in _-___ are associated with
- multiple endocrine neoplasia (MEN) syndromes
- familial medullary thyroid carcinoma
Germline point mutations in c-ret are associated with
- multiple endocrine neoplasia (MEN) syndromes
- familial medullary thyroid carcinoma
Gastrointestinal tumors (GISTs)
Germline mutations in _-___ .
GISTs
Germline mutations in c-kit
[t(5;12)] generates a fusion protein between the PDGF receptor and another motif, resulting in _____ _____.
t(5;12) generates a fusion protein between the PDGF receptor and another motif, resulting in myelomonocytic leukemia.
DNA viruses and cancer
HPV - _____ cancer
EBV - _____ lymphoma; _____ carcinoma
DNA viruses and cancer
HPV - cervical cancer
EBV - Burkitt lymphoma and Nasopharyngeal carcinoma
_____ benign smooth muscle tumors of the uterus.
Leimyomas are benign smooth muscle tumors of the uterus.
A _____ is a benign mesenchymal tumor of the left atrium.
A myxoma is a benign mesenchymal tumor of the left atrium.
_____
Tumor marker for T-cell malignancies.
CD4
Tumor marker for T-cell malignancies.
HMB-45, S-100 protein
Tumor markers for _____ _____.
HMB-45, S-100 protein
Tumor markers for malignant melanoma.
_____
Tumor marker for muscle tumors.
Desmin
Tumor marker for muscle tumors.
_____
Tumor marker for medullary carcinoma of the thyroid.
Calcitonin
Tumor marker for medullary carcinoma of the thyroid.
Routes of _____ _____.
- Hematogenous
- Lymphatic
- Seeding of body cavities
Routes of tumor metastasis
- Hematogenous
- Lymphatic
- Seeding of body cavities
A malignant tumor of epithelial origin is a _____
A malignant tumor of mesenchymal origin is a _____
A malignant tumor of epithelial origin is a carcinoma
A malignant tumor of mesenchymal origin is a sarcoma