General Mechanism of Action

Question 1

hypothalamic control of the HP axis is…

Answer 1

pulsatile; frequency varies

Question 2

direct effect

Answer 2

pituitary hormone’s effect on the primary target

Question 3

indirect effect

Answer 3

secondary hormone’s effect on the secondary target

Question 4

exception to the negative feedback paradigm

Answer 4

estrogen

Question 5

somatotrophic hormones

Answer 5

growth hormone and prolactin
have spillover
tyrosine kinase receptors

Question 6

glycoprotein hormones

Answer 6

luteinizing hormone, follicle stimulating hormone and thyroid stimulating hormone
heterodimers (alpha and beta subunits; alpha identical)
GPCR receptors
Chorionic gonadotropin is also a member
manufacture difficult (glycosylation different)

Question 7

POMC derived hormones

Answer 7

ACTH

Question 8

result of resection of pituitary

Answer 8

death from lack of cortisol

Question 9

causes of lack of hormone

Answer 9

incomplete biosynthesis
reduced signal
hyperplasia/neoplasia of the synthetic gland
loss of the gland
iatrogenic suppression

Question 10

nonfunctioning hormone

Answer 10

altered form
altered receptors = hormone resistance
post-receptor activity = hormone resistance
inappropriate secretion of the hormone

Question 11

disease/treatment modification

Answer 11

trauma/stress
impaired hormone metabolism
drug interactions

Question 12

hormone excess

Answer 12

loss feedback regulation

neo/hyperplasia