General Hormones Flashcards
ACTH
Adrenocorticotropic hormone, corticotropin
Activated by CRF (corticotropin-releasing factor)
Controls cortisol production in adrenal gland
TSH
Thyroid-stimulating hormone, thyrotropin
Upregulated by TRH
↑T3, T4 upon stress
FSH
follicle-stimulating hormone
stimulate estrogen and progesterone/testosterone and sperm
GnRH
follicle development
downregulated by progesterone and estrogen
LH
luteinizing hormone
stimulate estrogen and progesterone/testosterone and sperm
GnRH
causes ovulation
PRL
Prolactin
milk production
supressed by dopamine
inhibits GnRH and FSH
ADH
anterior pituitary, neurohormone
Vasopressin
Contracts smooth muscle, raises blood pressure
allows water to diffuse into the blood (recruits aquaporins)
oxytocin
made in hypothalamus, released by posterior pituitary
↑ during orgasm and hugging, during labour
contractions of uterus
hGH
released from anterior pituitary
somatotropin, human growth hormone
Provides nutrients for ATP synthesis
adipose tissue –> ↑lipolysis (↓cholesterol) –> ↑FFA and glycerol
muscles –> ↑ protein synthesis, glucose, AA
bones –> ↑glucose, AA, protein synthesis, BMD, chondrogenesis
Liver –> ↑ gluconeogenesis, glycogenolysis
↑IGF-1
↑Cardiac function
↑muscle mass, strength
IGF-1
somatomedin, insulin-like growth factor
inhibits GHRH
GHIH
somatostatin
Aldosterone
mineralocorticoid
produced in adrenal gland
salt and water balance, blood pressure
Cortisol
glucocorticoid
maintains blood sugar and blood pressure, antiinflamamtion
What increases insulin secretion
↑glucose, FFA, AA incretins (gastrin,cholecystokinin, GIP) glucagon, GH, cortisol PSN (acetylcholide) beta adrenergic simulation insulin resistance
glucagon
Ghrelin
↑Appetite, fat deposition
↑GH release
Leptin
↓appetite
from white adipose tissue
triggered by insulin and emotional stress
less leptine –> less POMC (makes ACTH) –> less cortisol
less leptine –> more neuropeptide Y, stimulated carbohydrate intake
CCK
cholecystokinin
peptide
fat and protein digestion
PYY
Peptide tyrosine tyrosine
↓appetite, limit food intake
estrogen
Growth of tissues of sex organs
Strengthens bones, protective effect on the hearth
progesterone
stimulates uterus lining for fertilization
inhibits FSH and LH
androgen
kick starts puberty, stimulates pubic and underarm hair
testosterone is an androgen
Testosterone
hair growth, muscle development, bone strengthening
Corticosteroid
Produced in adrenal gland
Anti inflammatory, blood sugar levels, muscle strength
ex: prednisone
globulin
protein, immune clotting
albumin
protein, colloid osmotic pressure
fibrinogen
protein, blood coagulation
Catecholamines
tyrosine and AA derived
dopamine, Ne, serotonin
What decreases insulin secretion
↓blood glucose fasting GHIH alpha-adrenergic activity leptin (hunger inhibition)
Insulin promotes
↑Glucose effect
↑Glycolysis
↑Glycogen synthesis
↑protein synthesis
Insulin inhibits
gluconeogenesis, glucigenolysis, lipoysis, ketegenesis, proteolysis