General Gynae 2 Flashcards
What chromosomes in Turner’s syndrome?
45X
Those with Turner’s syndrome are prone to: (x4)
diabetes
otitis media
coarctation of the aorta
renal malformations
Name some physical features you might expect to see in a girl with Turner’s syndrome.
webbed neck
short stature
low set ears
increased carrying angle @ elbow
Do girls with Turner’s syndrome have a normal vagina and womb?
yes
Do girls with Turner’s syndrome have normal intelligence?
YES
When is Turner’s syndrome often diagnosed?
age 13/14 when no puberty.
vagina and womb normal but ovaries don’t work properly
What’s wrong with the ovaries in Turner’s syndrome?
dont make enough oestrogen
dont make enough eggs
present at age 13/14 with no puberty
What treatments are required in Turner’s syndrome?
*think:
short stature
ovaries
complications.
- growth hormone therapy
- COCP (replace oestr + prog)
- monitoring for complications
What can be done if a girl with Turner’s syndrome wants to get pregnant?
donor eggs
growth hormone therapy
COCP
monitoring for complications
are treatments for…
Turner’s syndrome
47 XXY. What’s this?
Klinefelter’s
45X. What’s this?
Turner’s
What is the chromosomal make up of a boy with androgen insensitivity syndrome?
normal - 46XY.
he’s just insensitive to androgens.
What are chromosomes in Klinefelter’s?
47 XXY
Genetically male but female/ambiguous external characteristics - tall, no body hair, with abdominal testes and a womb.
androgen insensitivity syndrome
46XY but can’t respond to androgens
What treatments may be required in androgen insensitivity syndrome?
remove abdominal testes! (malig risk)
depends on what gender they identify as.
e. g. vaginal dilation / penis reconstruction
e. g. male breast reduction
Why is it important to surgically remove abdominal testes in androgen insensitivity syndrome?
risk of malignancy
Premature ovarian failure is defined as…
menopause <40
Name 3 causes of premature ovarian failure
- genetic
- chemotherapy
- autoimmune
Three investigation results which you’d expect to find in premature ovarian failure?
low oestrogen
high FSH/LH
When testing FSH for premature ovarian failure, you need …
2 raised samples of FSH 4 wks apart
35 yr old lady has low oestrogen, low AMH and high LH and high FSH (2 samples taken 4wks apart). What is likely diagnosis?
premature ovarian failure
What is the treatment for premature ovarian failure?
HRT / COCP
DONOR EGGS
testosterone might increase libido
36 yr old woman with premature ovarian failure is struggling with low libido. What might you prescribe?
testosterone gel
