General Dermatology Flashcards
Skin: Adnexal Structures
hair
nails
glands
sensory structures
Skin: basic role in brief
role in protection, homeostasis and transport of sensations
Sub cutis
– fat energy store, insulation, fibrous bands anchour skin to fascia
Dermis
- collagen and elastin matrix with mucopolysaccharide gel also fibroblasts, dermal dendritis cells and macrophages
Epidermis
Out layer – 3 cell types keratinocytes majority of cells
Melanocytes
– makes melanosomes (collections of melanin) excreted and phagocytoses into keratinocytes where they sit above the nucleus
Langerhans cells
– process antigens and migrate to lymph nodes to induce an immune response
Stratum Cornueum
Dead cells with a hard protein envelope; the cells contain keratin and are surrounded by lipids.
Stratum Lucidum
Dead cells lie within dispersed keratohyalin
Stratum Granulosum
Keratohyalin and a hard protein envelope for; lamellar bodies release lipids; cells die.
Keratin Granules
Stratum Spinosum
Keratin fibres and lamellar bodies accumulate
Stratum Basale
Cells divide by mitosis and some newly formed cells become the cells of the more superficial strata.
Basement membrane
Hemidesmosomes
Desmosomes connecting adjacent cells
Nail
Hyponychium Nail plate Lateral nail fold Nail bed Lunula Cuticle Proximal nail fold Nail matrix
External Causes:
Photosensitivity
Photosensitivity
Commonly caused by medications
Exposed sites affected
Can be sensitive to UVA, UVB, visible light or a combination of these.
External Causes: Cold
Cold Injury
Frostbite,
Chilblains
Skin Necrosis
Cold Urticaria
External Causes: Trauma
Dermatitis Artefacta
self-induced harm
Internal Causes:
Drug reaction
Vary in severity
Think of OTC drugs
Take a good history!
Internal causes: autoimmune
Bullous Pemphigoid
Describing skin lesions
Morphology is the appearance of skin lesions
Small usually means less than 5mm