General Anes Flashcards
1
Q
MOA of GA at inhibitory synapse
A
- enhance neurotransmission at inhibitory synapse
- allosterically increase sensitivity of gaba receptors sensitivity to gabag
- potentiation, increase cl- entry
- hyperpolarisation increases
- block neurotransmission because depolarisation harder to occur
2
Q
MOA of GA at excitatory synapse
A
- depress neurotransmission at excitatory synapse
- block glutamate from binding to NMDA receptors
- neurotransmission blocked
3
Q
Name some inhalation GA
A
- halothane
- isoflurane
- sevoflurane
- nitrous oxide
4
Q
halothane
A
- used for skeletal muscle
- little to no analgesia until unconsciousness
5
Q
isoflurane
A
- pungent
- start/ maintain GA
6
Q
halothane AE
A
- respi d
- hypotension, bradycardia, arrythmia
- hepatitis
7
Q
sevoflurane
A
- rapid onset and recovery
8
Q
isoflurane AE
A
- respi d
- less hypotension and arrythmia (than halothane)
- due to decreased systemic vascular resistance
9
Q
sevoflurane AE
A
- nephrotoxicity
- hepatoxicity
10
Q
nitrous oxide
A
- not potent due to high MAC (minimum alveolar concentration)
- analgesic and amnesia
- not used for complete unconsciousness and surgical anes
11
Q
what does MAC indicates
A
higher the MAC, the less potent the drug
12
Q
can nitrous oxide be used alone for GA?
A
NO
- only can use alone for analgesic effect: delivert and dentistry
13
Q
intravenous GA
A
- induces unconsciousness, not necessarily for long
- used with inhalation gas to decrease dose of inhaled gas, achieiving greataer effects than inhalation ga alone
14
Q
is ventilation needed when IV GA is administered?
A
YES because IV GA causes respiratory depression
15
Q
Name the IV GA
A
- thiopentone
- propofol
- ketamine
