General Anaesthesia

Question 1

what are the two main categories of general anaesthetics

Answer 1

1. those that are inhaled as vapour or gas

2. those that are injected intravenously

Question 2

what are the properties of inhalation anaesthetics

Answer 2

absorbed through lungs

gasses or volatile liquids

Question 3

name an inhalation anaesthetic

Answer 3

desflurane

Question 4

name an inhalation anaesthetic

Answer 4

isoflurane

Question 5

name an inhalation anaesthetic

Answer 5

sevoflurane

Question 6

what are inhalation anaesthetics often given with

Answer 6

nitrous oxide

Question 7

name an intravenous anaesthetic

Answer 7

thiopentone

Question 8

name an intravenous anaesthetic

Answer 8

propofol - now used increasingly for short duration operations and procedures

Question 9

name an intravenous anaesthetic

Answer 9

etomidate

Question 10

what one feature is common to all anaesthetics

Answer 10

lipid solubility

Question 11

which features increase potency of anaesthetics

Answer 11

unsaturation

Question 12

which features increase potency of anaesthetics

Answer 12

halogen substitution

Question 13

which features increase potency of anaesthetics

Answer 13

ether group C-O-C

Question 14

which features decrease potency of anaesthetics

Answer 14

hydrophilic groups OH NH2

Question 15

what is a feature common to all anaesthetics

Answer 15

bind to hydrophobic domain of proteins

Question 16

which proteins are most sensitive to the effects of anaesthetics

Answer 16

cns proteins - effects on neuronal functions - synaptic function is the most sensitive to the effects of anaesthetics

Question 17

how do anaesthetics work

Answer 17

potentiate GABA at GABAa receptors