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Biochemistry > General > Flashcards

General Flashcards

1
Q

Catabolic pathway activated by insulin

A
  1. Link reaction

2. Glycolysis

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2
Q

Catabolic pathways not act by glucagon

A

Glycolysis and link rxn

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3
Q

Insulin stimulates

A

Phosphodiesterase

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4
Q

Glucagon +

A

Adenyl cyclase

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5
Q

Catabolic in cytoplasm

A

Glycolysis

Glycogenolysis

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6
Q

Both mito and cytoplasm mei reactions

A

Hemesynthesis, urea cycle, gluconeo

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7
Q

Fat products that can be converted to glu

A

Glycerol, propionic acid

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8
Q

In b12 def, which accumulates
Propionyl coa
L MM COA

A

L mm coa

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9
Q

In b1
7 def, which accumulates
Propionyl coa
D MM COA

A

P ca

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10
Q

Fates of acetyl coa

A

Tca
Kb
Gluconeogenesis

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11
Q

Fate of acetyl coa in DM

A

Kb, gluconeogenesis

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12
Q

Fuel fetal heart, heart failure, rbc

A

All glucose

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13
Q

6 enzyme cartegories

A

OTHLIL

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14
Q

Nad and fad used in cat/ana

A

Cat

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15
Q

Nadp used in cat/ana

A

Ana

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16
Q

Nadph sources

A

Hmp
Malic enzyme
Cytoplasmix isocitrate dehydrogenase

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17
Q

Nadph fate

A

Reductive biosynthesis

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18
Q

Ec of dehydrigenase

A

1

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19
Q

Ec of reductase

A

1

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20
Q

Ec of kinase

A

2

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21
Q

Ec of phosohorylase

A

2

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22
Q

Ec of phosphatase

A

3

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23
Q

Mg ci factor for

A

Kinase
Phosphorylase
Carboxylase

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24
Q

Main co factor pyruvate kinase

A

K

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25
Q

Ec of synthase, synthetase

A

4,6

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26
Q

Ec Nitric oxide synthase

A

1

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27
Q

Ec citrate synthase and glycogen synthase

A

2

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28
Q

Ec of atp synthase

A

3

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29
Q

Vitamin for carboxylase

A

B7

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30
Q

Ec and vit for oxidative decarboxylase

A

1, b1

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31
Q

Ec and vit for simple decarboxylase

A

4, B6

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32
Q

Transport of endo fat

A

Vldl lp

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33
Q

Transport of exo fat

A

Chylomixron lp

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34
Q

Max sda

A

Prot

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35
Q

Aerobic and anaerobic glycolysis atps

A

7, 2

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36
Q

In rbc glycolysis atp

A

2

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37
Q

RL SHUNT occurs in

A

Rbc1

38
Q

Atp in rpl shunt

A

0

39
Q

Nadh gives how many atp

A

2.5

40
Q

Fadh2 gives how many atp

A

1.5

41
Q

2 shuttles

A

Mallate, glycerol phosphate

42
Q

Malate shuttle majorly in

A

Liver and heart

43
Q

Glycerol phosphate shuttle mostly in

A

Brain, muscle skeletal

44
Q

In aerobic glycolysis using g phosphate shuttle, how many atp produced

A

5

45
Q

Nadph via glycerol phosphate shuttle, how many atp

A

0

46
Q

Why doesn’t urea cycle occur in brain

A

Absence of ornithine transcarbomylase

47
Q

Total atp used in urea cycle

A

3 atp and 4 high energy phosphate

48
Q

Is musclr glycogen used for anaerobic glycolysis how many atp formed

A

3

49
Q

4 enzymes in beta oxidation of fa

A

Dehydrogenase
Hydratase
Dehydrogenase
Thiolase

50
Q

Net atp gain in even chain fa oxidation

A

108

51
Q

Net atp gain in odd chain fa oxidation

A

110

52
Q

No atp production in

A

Hmc, uronic acid pathway, oxidation of VLCFA, ALPHA OXIDATION OF FA, RL SHUNT

53
Q

Enzyne replacement therapy in lysosomal dis

A

Pompes, sphingo ( Goucher, NP, Fabrys), wolman, mps 1 , 2 , 6

54
Q

Names of 1,2,6 mps

A

Hurler, hunter, maroteaux lamy syndrome

55
Q

Deficiency in type 1 mps

A

Alpha L iduronidase

56
Q

Deficiency in type 2 mps

A

Iduronate sulfatase

57
Q

Inclusion body in ty1 mps

A

Reilly Body

58
Q

Deficiency in i cell disease

A

N-acetyl glucosamine phospho transferase

59
Q

Defected enzyme in which organelle in i cell dis

A

Golgi

60
Q

Def enzyme in pompe dis

A

Acid maltase

61
Q

Cystinosis treatment

A

Cysteamine

62
Q

Cyanide nitroprusside test positive in which lysosomal dis

A

Cystinosis

63
Q

Def enzyme in wolman dis

A

Acid lipase

64
Q

Lysosomal storage dis with calcification of adrenal

A

Wolmans

65
Q

Chilersteril ester storage disease

A

Wolmans

66
Q

X linked recessive MPS

A

Hunters

67
Q

Garrod tetrad

A

Cystinuria
Alkaptonuria
Albinism
Pentosuria

68
Q

Protein target disorder and lysosomal storage dis

A

I cell dis

69
Q

Lysosonal storage and glycogen storage dis

A

Pompe

70
Q

Deficiency in primary hyperoxaluria

A

Glycine transaminase

71
Q

Organelle affected in Zellweger dis

A

Peroxisome

72
Q

Defect present in what in cystic fibrosis

A

Ldl receptors

73
Q

Most common amino acid transporter dis

A

Cystinuria

74
Q

Chemically cystine made of

A

2 Cysteine and disulphide bond

75
Q

In cystinuria, increase level in serum and urine of

A

Serum cysteine

Urine cystine

76
Q

Most common amino acid disorder

A

Phenylketonuria

77
Q

Most common amino acid disorder

A

Phenylketonuria

78
Q

Phenylketonuria defect

A

Phenylalanine hydroxylase

79
Q

Essential amino acid in phenylketonuria

A

Tyrosine

80
Q

Mousy or musty odor

A

Phenylketonuria

81
Q

Best test for inborn errors of metabolism

A

Tandem mass spectrometry

82
Q

Enzyme defect alkaptonuria

A

Homogentisate dihydrogenase

83
Q

Maple syrup urine disease defect

A

Alpha keto acid dehydrogenase or decarboxylase

84
Q

Albinism enzyme defect

A

Tyrosinase

85
Q

Homocystinuria defect

A

Cystathione beta Synthase

86
Q

Amino acid disorder with cyanide nitroprusside test positive

A

Homocystinuria

87
Q

Mc galactosemia with deficiency

A

Classical,

GALT (GALACTOSE 1 PO4 URIDYL TRANSFERASE)

88
Q

Def in minor galactosemia

A

Galactokinase

89
Q

Oil droplet cataract in minor galactosemia d/t?

A

Galactitol

90
Q

Def in hereditary fructose intolerance

A

Aldolase b

Biochemistry (2 decks)

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