General Flashcards
What would you expect to see on histology of a wilms tumour?
small round blue cells
what is a condyloma
wart caused by HPV
What does a hydrocele form between?
between the tunica vaginalis layers - comes from a remnant of the processus vaginalis from the peritoneum
how do you remember vaccines
4 2 3 4
What would be seen on CT/MRI of tuberous sclerosis
tubers - calcified subependymal nodules
How do you remember tuberous sclerosis signs?
A SHLEAF spots S hagreen patches H eart rhabdomyosarcoma L ung hamartoma E pilepsy - due to calcifies subependymal nodules A ngiomyolipoma in kidneys F acial angiofibroma
What other conditions is neurofibromatosis assocaited with
MEN1 and 2b
what are the diagnostic criteria for neurofibromatosis
6 or more cafe au lait by puberty greater than 5mm (tend to grow in puberty so must be over 15mm then ) more than one neurofibroma axillary feckles optic glioma lisch nodule sphenoid dysplasia 1st degree relative
What is the difference between a medical and a surgical 3rd nerve pasly
Occulomotor nerve. blood supply limitation affects the inner motor supply first before the outer parasympathetic fibres meaning the pupil is still able to constrict - this is a medical palsy
When there is pressure from something compressing it - the parasympathetic nerves are blocked too and so the pupil is blown.and this may also cause pain.
What are the guidelines for status epilepticus
Midazolam0.5mg/kg/benzo 0.1mg/kg @5mins
Benzo@15mins - 0.1mg/kg IV
phenytoin infusion @25mins 20mg/kg over 20 mins (or phenobarbitol if on phenytoin 20mg/kg over 5 mins)
rapid sequence induction @45mins
How would iron overdose present
initially vomiting and diarhoea due to gastric irritation and then with haematemeis and malaena
Is Hep A a notifiable disease?
yes - you should do your best to not admit these patients due to risk of spread.
what is a meckels diverticulum
an ilael remnant of the embryological vitellointestinal duct which contains gastric mucosa. there is increased risk of ulceration and perf.
what is the first presentation of a migraine in childrren?
abdominal pain - it is usually assocaited with a strong family history and is a diagnosis of exclusion - there would be no blood.
It often occurs with a headacahe, and maybe vomiting with a pale face
What is toddler diarrhoea
Sometimes loose and explosive, other times well formed, most common cause in preschool children around the time of potty training. undigested food is common.
developmental delay of intestinal motility. usually grow out of the diarrhoea by 5 years of age however it can severely delay continence
making suer the diet contains more fat and fibre can help slow transit time.
when is the classic presentation of coeliac
8-24 months
What is acrodermatitis enteropathica
associated with zinc malabsorption - is chill when you give them zinc
moist erythematous plaques often symetrical on the buttock regions and are on face too.
When does malrotation usually occur and what causes it?
Usually in first few days of life with intestinal obstruction due to LADD bands.
Mcburneys point?
over appendix
What is infantile colic
few times a day particularly in the evning have to draw feet towards chest to relieve large vlumes of flatus
name some causes of crying in a baby which may not be obvious diagnnosis.
middle ear infection, fracture UTI, oesophagitis, tortid testicle teething.
What is the management for pyloric stenosis
Admit
intravenous fluids to return acid base and electrolytes to normal
consider pylormyotomy
what should the normal PH of the oesaphagus be
above 4
What is sandifer syndrome
dystonic neck posturing due to GORD.
What is the management of GORD
reassurance Thickening agents 30 degree prone posturing ranitidine or omeprazole nissen fundoplication
ertythema toxicum?
benign slef limiting rash thought to be due to allergy, colonisation of bacteria such as group b strep and adjustment to heat etc.
scalded skin syndrome?
staphylococcal scalded skin - due to release of exfoliative toxin. exhibit nikolksy sign - separation of epidermis on gentle sheering pressure
What are the conttraindications to the MMR?
non-HIV immunodeficiency and neomycin or kanamycin allergy
another live vaccine in the last month
What illnesses predominate in those with t cell deficiencies
Virus and fungal
What is duncan syndrome
Immune deficiency linked to uncontrollable EBV infection so they succumb to intial infection or develop a burkitts lymphoma
What is milia
white pimples on the nose and cheeks from keratin retention and sebaceous material in the follicles.
What is another name fro salmon patches and what are they?
stork bite often on eyelids forehead and nape of the neck from distention of dermal capillaires.
what is another name for neonatal urticaria
erythema toxicum
What is a port wine stain and what is the management?
darker more well demarkated red patch on the face due to vascular malformation of the capilliaries in the dermis. If they are in the trigeminal distribution they need an MRI to check for brain involvement. (sturge weber syndrome)
Management of a strawberry naevus
Watches closely until they are gone. regress after 3-15 months but are associated with complications. eg haemorrhage, thrombocytopenia, can get in way of vision or breathing.
What is caput succedaneum?
haemorrhage under the skin but above the aponeurosis.
What is the difference between subaponeurotic haemorrhage and cephalohaematoma.
under the aponeurois and does not bulge so much.
1 layer down under the periostium.
both are above the bone.
cephalohaematoma adheres to the margins of the bone.
What two infections commonly affect eczema?
staph and herpes simplex
What is the mechanism for ITP
immune breakdown usually IgG to Glp2b/3a they are opsonised and phagocytosed in the liver.
ADAMTS13 gene
TTP.
Does Hep B cause erythema nodosum?
no
Does OCP cause erythema nodosum?
yes
You find small white spots along the midline fo the palate in a baby? what are they? are they worrying?
epsteins pearls - no
cysts of the gums are not worrying either - epulis or ranula.
What are the phases of growth?
Fetal - 30% - mother factors
Infantile - 15% - Nutrition alone
Childhood - 40% - GH, IGF-1, thyroid, vit D, happiness.
Growth spurt - 15% - sex hormones - fusion of the epiphyseal plates.
What is the treatment for NEC
Broad spectrum abx and fluids
bowel wall odema, perf, free air? pneumatosis intestinalis
flushed appearance with perioral pallor
scarlet fever - usually rash on the trunk first like sandpaper. strep pyogenes usually. group A beta haemolytic strep. desquamation of fingers and toes later.
what is the management for scarlet fever?
mx
throat swab, pen v , 24 hours off school, notify the PHE.
What are the less well known sequelae of cystic fibrosis?
short delayed puberty diabetes nasal polyps male infertility and female subfertility
NO ARTHROPATHY
What is the infectivity window of chicken pox
4 days before rash and 5 days after onset
what is the incubation period for chicken pox
10-21 days
what is enucleation?
removal of the eye - can be a treatment for retinoblastoma
What are the 4 causes of jaundice in a baby less than 24 hours old?
rhesus haemolysis
ABO haemolysis
G6PD
hereditary spherocytosis
What are the causes of jaundice after 2 weeks?
BBC HUG biliary atresia Breast milk jaundice congenital infection e.g CMV/TOXO hypothyroidism UTI galactosaemia
What drug is used to stop bleeding in von willebrands disease
desmopressin
What is found in the GI tract of peutz jeugers? what other signs do they show?
hamartomatous polyps which need to be kept under close observation
pigmentation around mouth and on hands and soles.
50% die from GI cancer by age 60
What is the name for infection of the umbilicus?
omphalitis - usually staph aureus
What is an umbilical granuloma
cherry red lesions around the umbilicus
require silver nitrate or corterization
persistent urachus
wee out of the umbilicus
ASOT titre will help diagnose what? and what is the cutoff?
rheumatic fever >200iu/mL
what is keratoconjuctivitis?
inflammation of cornea and conjuctiva
is infertility assocaited with measles
no
what should an unvaccinated child do if the come into contact with measles
vaccinate within 72 hours
What kind of fever is bronchiolitis assocaited with
low grade.
what is salmeterol
long acting beta agonist
how does episodic viral wheeze present?
wheeze inhale and exhale. often along with an URTI of viral origin.
treatment is symptomatic only
first-line is treatment with short acting beta 2 agonists (e.g. salbutamol) or anticholinergic via a spacer
next step is intermittent leukotriene receptor antagonist (montelukast), intermittent inhaled corticosteroids, or both
If they are symptomatic betwwen URTI’s and it is thought there are other triggers such as exercise then they should be given montelukast and inhaled corticsteroid for 4-8weeks. this is know as a multiple trigger wheeze
congenital syndrome associated with sensorineural deafness
rubella
What is the most common type of brain tumour in children?
astrocytoma can be benign or malignant (glioblastoma multiforme) These account for 40% of the tumours.
20% will be medullablastoma and will be found in the midline of the posterior fossa
mostly infratentorial and prmary.
what is the squamous remnant from rathke’s pouch?
craniopharyngioma
how does a craniopharyngoma present?
bitemporal inferior quadrantanopia
gas cysts in bowel wall
NEC
what is riglers sign
air inside and outsie the bowel
What would you elicit on palpation of a kidney containing cysts?
often pain
What are the features of typhoid
relative bradycardia and splenomegaly aswell as rose spots and constipation or diarrhoea
What are the features of mono
sore throat lymphadenopathy splenomegaly in 50% (no contact sports for 8 weeks or may rupture) headache malaise haemolytic anaemia with cold agglutitins
How do you test for mono
monospot test in the 2nd week of illness also know as the heterophile antibody test or the paul bunnel
What bacteria are most likely to cause conjuctivitus in a child
HIb and strep.
What screening test is used for strabismus
corneal light reflection test
What are the contraindications to lumbar puncture
reduced GCS less than 9 or fluctuating conciousness focal neurology dilated pupils papillodema abnormal dlls eye movements relative bradycardia and hypertension
at whsat time of year does SIDS occur most?
winter
what are the risk factors for SIDS
maternal drug use twin male sex bottle feeding overwrapping smoking prematurity social classes 4 and 5
siblings should be screened for inborn errors of metabolism.
What are the assocaited non-motor problems in CP?
learning difficulties (60%) epilepsy (30%) squints (30%) hearing impairment (20%)