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DPD interactive cases > General (6) > Flashcards

General (6) Flashcards

(103 cards)

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1
Q

Describe the presentation of anaphylaxis.

A

Sudden-onset following a trigger
Breathlessness
Facial swelling
Hypotension

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2
Q

What is the first step in the management of anaphylaxis?

A

IM adrenaline

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3
Q

When is IV adrenaline used?

A

Cardiac arrest (0.5)

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4
Q

What are the three drugs used in the treatment of anaphylaxis? State their relative proportions.

A

Adrenaline – 1 mg
Chlorpheniramine – 10mg
Hydrocortisone – 100mg

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5
Q

Which antibiotics are used in the treatment of community-acquired pneumonia? Explain why each of them is used.

A

Amoxicillin – covers the most common cause of CAP (Streptococcus pneumoniae)
Clarithromycin (oral) – a macrolide that covers atypical organisms

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6
Q

Which drug is used to treat hospital-acquired pneumonia and which bacteria does it cover?

A

Tazocin – covers Gram-negatives

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7
Q

Which drug is used in patients with suspected MRSA?

A

Vancomycin

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8
Q

List some atypical organisms that can cause pneumonia.

A

Mycoplasma pneumoniae
Chlamydia pneumoniae
Legionella pneumophilia (40% of CAP)

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9
Q

What would be your first investigation in a patient presenting with dyspepsia and weight loss?

A

OGD

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10
Q

If no abnormality is detected with this investigation, what would you do next?

A

Colonoscopy

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11
Q

How would you investigate microcytic anaemia?

A

Haematinics – iron studies (e.g. ferritin, folate and B12)

Ferritin and Folate is an acute phase protein; raised in Inflamx Infx and Malig.

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12
Q

What must you bear in mind when looking at serum ferritin levels?

A

Coeliac disease; systemic AI condition bc gluten peptides (wheat, barley, rye); affects 1%.

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13
Q

Which other test would you perform in a patient with GI disturbance and microcytic anaemia?

A

Tissue transglutamine antibodies (tTG)

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14
Q

Which other test must you do alongside the tTG?

A

Serum IgA levels (because IgA deficiency can give false-negative tTG results)

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15
Q

How is a diagnosis of coeliac disease confirmed?

A

Duodenal biopsy – shows subtotal villous atrophy with crypt hyperplasia

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16
Q

What is a common hospital-acquired cause of explosive bloody diarrhoea? What is the major risk factor?

A 
Pseudomembranous colitis (C. difficile colitis)
Antibiotic use is the main risk factor
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17
Q

What 2 differentials must you consider in an elderly patient with bloody diarrhoea?

A

Ischaemic colitis - affects small vessels, as opposed to mesenteric ischaemia
Pseudomembranous colitis

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18
Q

List a differential diagnosis of bloody diarrhoea.

A 
Infective colitis 
Inflammatory (e.g. IBD)
Ischaemic colitis 
Malignancy
Diverticulitis
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19
Q

How would you treat a patient with AF, presenting 4 hours after the onset of symptoms?

A

DC cardioversion

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20
Q

Which drug can be used to chemically cardiovert pretty much all arrhythmias?

A

Amiodarone

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21
Q

Describe the direction of blood flow in the veins involved in caput medusa.

A

Below the umbilicus, the blood within the veins flows towards the legs

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22
Q

What are the two Trousseau’s signs?

Whats the Troisier sign?

A

Trousseau’s sign of latent tetany – in patients with hypocalcaemia, inflation of a blood pressure cuff around the arm leads to carpopedal spasm
Trousseau’s sign of malignancy – thrombophlebitis occurring as an early sign of gastric or pancreatic cancer

Troisier’s - enlarged L SupraV LN due to 2ndary enlargment

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23
Q

Portal hypertension may present with signs of decompensated liver failure. Give some examples of such signs.

A

Encephalopathy
Ascites
SBP
Variceal bleed

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24
Q

What is another name for target cells?

A

Codocytes

NOTE: they have an increased red cell surface membrane

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25
What are target cells a sign of?
Hyposplenism
26
What is microangiopathic haemolytic anaemia?
Breakdown of red blood cells in small vessels
27
Describe how DIC causes haemolytic anaemia.
Clots form in narrow vessels; fibrin strands trap RBC, cannot easily pass through so end up haemolysing It is a process of repeatedly making and breaking clots and is seen in very sick patients (e.g. sepsis)
28
Why are DIC patients prone to bleeding?
It leads to the consumption of all the clotting factors meaning that clotting is impaired
29
List the main features of DIC on a blood test.
Low platelets + low fibrinogen High PT/APTT High D-dimer/fibrin degradation products (fibrinolysis)
30
List the main features of HUS on a blood test.
Haemolysis -> low Hb + high bilirubin Uraemia -> high urea (due to abnormal renal function) Thrombocytopaenia (Triggered by Haemolytic E. Coli 0157)
31
What is TTP?
HUS + fever + neurological manifestations
32
List some hereditary causes of haemolytic anaemia.
Cell Membrane Defects – hereditary spherocytosis Enzyme Defects – G6PD deficiency, pyruvate kinase deficiency Haemoglobinopathies – sickle cell disease, thalassemia
33
List some acquired causes of haemolytic anaemia.
``` Drugs Autoimmune haemolytic anaemia SLE Infection (e.g. malaria) MAHA ```
34
How can you differentiate small bowel from large bowel on an abdominal X-ray?
Small Bowel - < 3 cm + valvulae conniventes (Kerckring's folds) Large Bowel - < 6 cm + haustra
35
Outline the management of bowel obstruction.
NBM | Drip and suck (IV fluids + aspirate stomach contents using NG tube)
36
What is the normal range for serum sodium?
135-145 mEq/L
37
What must you assess first in a hyponatraemic patient?
Volume status
38
List some features of hypovolaemic patients
Postural hypotension Dry mucous membranes Tachycardia Reduced tissue turgor This leads to decreased urine Na as kidney's trying to reabsorb - this is a good sign in hyponatremia
39
List some features of hypervolaemic patients
Peripheral oedema Increased JVP Fluid retention
40
List the main causes of hyponatraemia associated with hypovolaemia
``` Diarrhoea Vomiting Diuretics Loss to skin, peritoneal cavity (pancreatitis) i.e. extra-renal fluid loss ```
41
List the main causes of hyponatraemia associated with euvolaemia
Adrenal insufficiency (urinary sodium = high) Hypothyroidism SIADH
42
List the main causes of hyponatraemia associated with hypervolaemia
Heart failure Cirrhosis Nephrotic syndrome
43
Which hormone is in excess if you have too much water in your system?
ADH
44
What can cause high ADH?
Appropriate elevation in response to hypovolaemia SIADH: increased water absorption, blood volume expansion, natriuretic peptide -> decreased Na+ (Treat SIADH w/ fluid restriction)
45
Describe the pattern of plasma sodium and urine sodium in SIADH.
Low plasma sodium (osmolality) | High urine sodium (osmolality)
46
Why might you perform a CXR or Brain MRI in a patient with euvolaemic hyponatraemia?
CXR – look for lung pathology that might be a source of ectopic ADH Brian MRI – look for CNS pathology that might be a source of ectopic ADH
47
Describe the urine sodium levels in a patient with hypovolaemic hyponatraemia.
Low urine sodium – the kidneys are trying to retain as much water and salt as possible
48
What might make the interpretation of urine sodium difficult?
Use of diuretics
49
Which investigations might you perform in a patient with euvolaemic hyponatraemia?
TFTs Short synacthen test Check plasma and urine sodium
50
Describe the urine sodium levels in a patient with hypervolaemic hyponatraemia. Explain why this is the case.
Low urine sodium – this is because the conditions that cause hypervolaemic hyponatraemia lead to increased aldosterone secretion (which increases sodium reabsorption in the kidneys)
51
Almost all causes of hyponatraemia are associated with high ADH. List two rare causes.
Excessive water intake | Sodium-free irrigation solutions (e.g. used in TURP)
52
List some causes of SIADH.
CNS pathology (e.g. stroke, tumour, abscess) Lung pathology (e.g. pneumonia, PE, lung cancer) Drugs Tumours (Ectopic ADH)
53
List some drugs that can cause SIADH.
``` SSRIs TCAs Opiates PPIs Carbamazepine ```
54
What can happen if you correct hyponatraemia too rapidly?
Cerebral oedema -> central pontine myelinolysis
55
What is the maximum rate at which you should correct hyponatraemia?
8 mmol/24 hrs
56
Outline the treatment of: | hypovolaemic hyponatraemia
IV fluids
57
Outline the treatment of euvolaemic hyponatraemia | What is dangerous to give?
Fluid restriction NOTE: normal saline may be dangerous in these patients because it increases plasma sodium leading to more fluid retention
58
Under what conditions do you give hypertonic saline to patients with euvolaemic hyponatraemia?
If the patient is fitting or has a low GCS
59
What is onycholysis?
Separation of the nail from the nail bed
60
List 4 causes of onycholysis.
Trauma Thyrotoxicosis Psoriasis Fungal infection
61
What are beau’s lines and what are they caused by?
Alternating dark and white lines in the nail Occur in patients with recurrent episodes of illness of chemotherapy (due to arrest of growth, then growth, then arrest of growth etc.)
62
What is koilonychias and what is it caused by?
Spooning of the nail | Caused by severe iron deficiency anaemia
63
What is nail pitting a sign of?
Psoriasis
64
What is leukonychia a sign of?
Hypoalbuminaemia, liver disease
65
Which blood results must you be aware of to diagnose DKA?
High capillary/blood glucose Acidosis Capillary ketones
66
List the complications of diabetes mellitus:
Microvascular - Retinopathy - Nephropathy - Neuropathy Macrovascular - Ischaemic heart disease - Cerebrovascular disease - Peripheralvascular disease Metabolic - DKA - Hyperosmolar hyperglycaemic state (HHS) - Hypoglycaemia
67
Describe the main ECG change seen in pericarditis.
Widespread saddle-shaped ST elevation
68
Describe the ECG change seen in left ventricular hypertrophy.
Deep S wave in V1 Tall R wave in V6 The total of the two will be > 7 large squares
69
If renal colic is suspected, which form of imaging should you request? What does it show?
Non-contrast CT-KUB - can show: - Pelvi-ureteric junction obstruction - Calculus within dilated renal pelvis
70
If you’re in clinic and a patient presented with symptoms of hyperparathyroidism and you want to check whether they have kidney stones, which imaging modality would you use?
Abdominal ultrasound
71
List some possible causes of high calcium and low PTH.
``` Malignancy Sarcoidosis Multiple myeloma TB, lymphoma (?PTHrp is driving the Ca) ```
72
Which diseases can cause hypercalcaemia and back pain?
``` Bone metastases Multiple myeloma (normal ALP) ```
73
What are the two main sources of ALP?
Bone | Liver
74
Which type of liver disease causes a rise in ALP?
Obstructive liver disease (also causes a rise in GGT)
75
List three bone diseases that are associated with a rise in ALP.
Fractures Malignancy Paget’s disease
76
Which bone cells produce ALP?
Osteoblasts
77
Which condition that causes bone pain is associated with normal ALP?
Multiple myeloma
78
What defines multiple myeloma and what are the 4 main features?
Differentiated plasma cells, infiltration of BM, presence of monoclonal Ig or Ig fragment in serum +/or urine M-protein i nserum >30g/L or BM clonal plasma cells >10% ``` 1 or more of following: Calcium (high) Renal impairment Anaemia Bone pain ```
79
Which type of benign breast lump is common in young women?
Fibroadenoma – smooth and mobile
80
Which cause of breast lump is exclusive to lactating women?
Galactocoele Retention cyst conaining milk located in mammary gland Also common in preg, post partum
81
What do most patients with fat necrosis causing a breast lump have a history of?
Trauma to the breast
82
List some causes of cavitating lung lesions.
Infection – TB, Staphylococcus aureus, Klebsiella (e.g. alcoholics) Inflammation – rheumatoid arthritis, granulomatosis with polyangiitis (Wegener’s granulomatosis) Infarction – PE (bland and septic) Malignancy (SqCC - bronchogenic)
83
What three things must you consider in patients with peripheral oedema?
Does the patient have heart failure? Is the patient losing albumin in their bowels? Is the patient losing albumin in their urine?
84
Which test can be performed to check for loss of protein in the urine?
Urinalysis | Then 24hr urinary protein
85
What is nephrotic syndrome caused by?
An increase in the permeability of the glomerular basement membrane to protein
86
What triad defines nephrotic syndrome?
Proteinuria > 3.5 g/day Hypoalbuminaemia Oedema
87
What are people with nephrotic syndrome susceptible to and why?
Increased risk of thromboembolic disease (due to loss of natural anticoagulants in the urine along with protein) Patients may present with renal vein thrombosis
88
What is hereditary haemorrhagic telangiectasia and what might these patients present with?
Autosomal dominant condition in which abnormal blood vessels form in the skin, mucous membranes, lungs, liver and brain, AV malformations The abnormal vessels are prone to bleeding SYMPTOMS: recurrent nose and GI bleeds, haemoptysis
89
What is Peutz-Jegher’s syndrome?
Autosomal dominant condition characterised by the development of benign hamartomatous polyps in the GI tract and hyperpigmented macules on the lips and oral mucosa
90
If a short synacthen test fails to cause a significant rise in cortisol, what is the diagnosis?
Adrenal insufficiency
91
What are the two main pathological reasons for a patient might have a high prolactin?
Prolactinoma Compression of the pituitary stalk (e.g. by a pituitary tumour) leading to a disruption of the flow of dopamine (which exerts an inhibitory effect over prolactin release) – disconnection hyperprolactinaemia
92
What diagnostic test is done for acromegaly?
Oral glucose tolerance test (OGTT) Failure of suppression of GH by the administration of glucose suggests acromegaly NOTE: another test involves the measurement of IGF-1, which will be high in acromegaly
93
What is the diagnosis in a patient with high FSH/LH but low oestrogen?
Premature ovarian insufficiency (radiotherapy, chemotherapy, AI)
94
Why does primary hypothyroidism lead to a mild hyperprolactinaemia?
Hypothyroidism leads to an increased production of TRH by the hypothalamus TRH has a stimulatory effect on prolactin release by the anterior pituitary
95
What is the most common cause of hyperprolactinaemia?
Pregnancy
96
Symptoms of pyelonephritis
Fevers, Rigors, Pain when tapping renal angle, increased CRP
97
How does TB, sarcoidosis and lymphoma change calcium studies?
``` The granulomas (macrophages) an hydroxylate vitamin D --> activation Increased Ca; decreased PTH ```
98
How to diagnose MM?
Serum/urine electrophoresis - Paraprotein spike IgG >35g/L or IgA >20g/L and light chain urinary excretion >1g/day Skeletal survey - osteopenia, osteolytic lesions, pathological fracture. BM aspirate and biopsy - plasma cell infiltration >10% to DDx from MGUS and solitary plasmacytoma
99
Rarer causes of cavitaing lesions
Trauma (pneumoceles in infancy) - intrapulmonary airfilled cystic spaces. Youth - CPAM, pulmonary sequestration, bronchogenic cyst
100
What does systemic sclerosis give you?
Microstomia | Tight Skin
101
How do you treat HHS
Fluids, K+, insulin
102
How do you treat hypoglycaemia?
Confused but cooperative: buccal dextrose gel | V confused: IV 10%/20% glucose or IM glucagon
103
Why is the ALP in MM normal?
Plasma cells produce paraprotein monoclonal Ig and suppress osteoblasts, which usually produces ALP

DPD interactive cases (8 decks)

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