General

Question 1

What is the function of the BRCA genes?

Answer 1

Tumor suppressor genes. They enable homologous recombination following dsDNA breaks.

Question 2

Which BRCA type is more associated with breast / ovarian? Which gives higher risks of prostate, pancreas, melanoma, GB / cholangio, stomach?

Answer 2

1. BRCA 1

2. BRCA 2

Question 3

What is the lifetime risk of developing breast cancer for a woman with a BRCA mutation?

Answer 3

50-75%

Question 4

What is the risk of developing ovarian cancer for BRCA1?

Answer 4

30-40%

Question 5

How much can prophylactic oophorectomy reduce risk of ovarian CA in BRCA?

Answer 5

~85%

Question 6

How much can prophylactic mastectomy reduce risk of breast cancer for high risk patients?

Answer 6

> 90%

Question 7

When do most recurrence occur for triple negative breast cancer?

Answer 7

Within 2-5 years of diagnosis

Question 8

When should FISH be sent for Her2 analysis?

Answer 8

Send on all IHC 2+ tumors

Question 9

What are the more favorable molecular subtypes of breast cancer?

Answer 9

Luminal A or Luminal B (ER/PR positive)

Question 10

What are the poor risk molecular subtypes of breast cancer?

Answer 10

HER 2 enriched (ER/PR negative)

Basal-like / triple negative

Question 11

ECOG 1

Answer 11

Restricted from strenuous physical activity. Able to perform light work.

Question 12

ECOG 2

Answer 12

Capable of ALL self care but no work. Up and about > 50% of waking hours.

Question 13

ECOG 3

Answer 13

Capable of only limited self care. Confined to bed or chair > 50% of waking hours.

Question 14

ECOG 4

Answer 14

Completely disabled. No self care. Totally confined to bed or chair.