General

Question 1

Inhibits peptidoglycan synthetase and polymerization of linear peptide

Answer 1

Vancomycin

Question 2

Bacitracin and cycloserine are inhibitors of ___________

Answer 2

cell wall synthesis

Question 3

Inhibits 30s ribosome and causes misreading of mRNA

Answer 3

Aminoglycosides

Question 4

Inhibits peptidyl transferase and peptide band formation

Answer 4

Chloramphenicol

Question 5

Inhibits 50s ribosome

Answer 5

LEC

Lincomycin, erythromycin, and clindamycin

Question 6

Inhibits binding of aminoacyl tRNA to 30s ribosome

Answer 6

Tetracyclines

Question 7

Inhibits 23s ribsome

Answer 7

Streptogramins/Linezolid

Question 8

Cation detergent agents disrupting cell membrane

Answer 8

Polymixin B, Colistin

Question 9

Use azole and polyene for

Answer 9

fungus

Question 10

Inhibits DNA-dependent RNA polymerase

Answer 10

Rifampin

Question 11

Interferes with supercoiling of DNA by action on DNA gyrase (topoisomerase 2)

Answer 11

Fluoroquinolones

Question 12

Inhibits lipid synthesis

Mediator of metabolism

Answer 12

Isoniazid and ethambutol

Question 13

Prevents synthesis of folic acid

Answer 13

Sulfonamides and trimethoprim

Question 14

Bacteria can pump out of cell

Answer 14

tetracyclines

Question 15

Bacteria can inactivate enzymes

Answer 15

Aminoglycosides

Question 16

Bacteria can produce beta-lactamases, change PBPs and porins

Answer 16

Pencillins/Cephalosporins

Question 17

Bacteria can increase PABA formation and change target enzyme sensitivity

Answer 17

Sulfonamides

Question 18

Bacteria can make methyltransferases that alter drug binding site on 50s

Answer 18

Macrolides

Question 19

Bacteria can pump drug out of cell and make target enzyme changes

Answer 19

Fluoroquinolones

Question 20

Piddly bugs

Answer 20

Haemophilus, morexella, morganella, shigella, salmonella

Sometimes providenicia and neisseria

Question 21

Fence Bugs

Answer 21

PEK (peking at the fence)

Proteus, e. coli, klebsiella

Question 22

SPACE bugs

Answer 22

Serratia, pseudomonas, acinetobacter, citrobacter, enterobacter

Question 23

Atypicals

Answer 23

MCL

Mycoplasm, chlamydia, legionella

Question 24

PBC

Peptostreptococcus, bacteroides, and clostridium

Answer 24

Anaerobes

Question 25

Prevents cross linking of peptidoglycan strands by inhibiting transpeptidases

Answer 25

Penicillins/Carbapenems/Cephalosporins/Aztreonam