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General Principles Anti-Infective Drugs > General > Flashcards

General Flashcards

1
Q

Inhibits peptidoglycan synthetase and polymerization of linear peptide

A

Vancomycin

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2
Q

Bacitracin and cycloserine are inhibitors of ___________

A

cell wall synthesis

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3
Q

Inhibits 30s ribosome and causes misreading of mRNA

A

Aminoglycosides

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4
Q

Inhibits peptidyl transferase and peptide band formation

A

Chloramphenicol

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5
Q

Inhibits 50s ribosome

A

LEC

Lincomycin, erythromycin, and clindamycin

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6
Q

Inhibits binding of aminoacyl tRNA to 30s ribosome

A

Tetracyclines

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7
Q

Inhibits 23s ribsome

A

Streptogramins/Linezolid

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8
Q

Cation detergent agents disrupting cell membrane

A

Polymixin B, Colistin

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9
Q

Use azole and polyene for

A

fungus

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10
Q

Inhibits DNA-dependent RNA polymerase

A

Rifampin

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11
Q

Interferes with supercoiling of DNA by action on DNA gyrase (topoisomerase 2)

A

Fluoroquinolones

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12
Q

Inhibits lipid synthesis

Mediator of metabolism

A

Isoniazid and ethambutol

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13
Q

Prevents synthesis of folic acid

A

Sulfonamides and trimethoprim

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14
Q

Bacteria can pump out of cell

A

tetracyclines

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15
Q

Bacteria can inactivate enzymes

A

Aminoglycosides

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16
Q

Bacteria can produce beta-lactamases, change PBPs and porins

A

Pencillins/Cephalosporins

17
Q

Bacteria can increase PABA formation and change target enzyme sensitivity

A

Sulfonamides

18
Q

Bacteria can make methyltransferases that alter drug binding site on 50s

A

Macrolides

19
Q

Bacteria can pump drug out of cell and make target enzyme changes

A

Fluoroquinolones

20
Q

Piddly bugs

A

Haemophilus, morexella, morganella, shigella, salmonella

Sometimes providenicia and neisseria

21
Q

Fence Bugs

A

PEK (peking at the fence)

Proteus, e. coli, klebsiella

22
Q

SPACE bugs

A

Serratia, pseudomonas, acinetobacter, citrobacter, enterobacter

23
Q

Atypicals

A

MCL

Mycoplasm, chlamydia, legionella

24
Q

PBC

Peptostreptococcus, bacteroides, and clostridium

A

Anaerobes

25
Q

Prevents cross linking of peptidoglycan strands by inhibiting transpeptidases

A

Penicillins/Carbapenems/Cephalosporins/Aztreonam

General Principles Anti-Infective Drugs (1 decks)

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