general Flashcards
why is type O blood considered the universal donor?
no antigens on surface
cannot be recognised by recipient’s antibodies even if different blood type
why can type O blood not receive blood from any other types but O?
the plasma produces both A and B antibodies which will recognise the transfused A and B antigens
initiating an immune response to recognised foreign cells
why can type AB receive blood from any group?
A and B antigens present and so plasma produces no antibodies
why can type AB not donate to any group but AB?
A and B antigens present
recognised by all other blood groups as foreign due to A and B antibodies
what is Cryoprecipitate?
a blood component derived from plasma.
When plasma is frozen and then thawed, formed is a precipitate of proteins called cryoprecipitate.
- rich in clotting factors, particularly fibrinogen, Factor VIII, von Willebrand factor, and Factor XIII
why is Cryoprecipitate important in transfusion science? when and how is it used?
commonly used in transfusion medicine to treat patients with bleeding disorders or deficiencies in clotting factors. It can be administered to individuals with conditions such as haemophilia, von Willebrand disease, or certain types of coagulopathies.
The fibrinogen found in cryoprecipitate is particularly important for clot formation. Factor VIII is essential for the intrinsic pathway of blood coagulation, while von Willebrand factor helps platelets adhere to damaged blood vessels, promoting clot formation. Factor XIII stabilises fibrin clots, contributing to their strength and durability.
what is FFP?
FFP = fresh frozen plasma
why is FFP important? when and how is it used?
Preserves clotting factors
including fibrinogen, Factor VIII, Factor IX, von Willebrand factor, and various other coagulation factors, as well as albumin and immunoglobulins
Important when trading patients with coagulation disorders such as DIC
