General Flashcards
Phase 2 …glucuronic acid ?
(🧑⚕️MAC)
Aspirin …morphine….chloramphenicol
Phase 2…Acetic acid (acetylation)?
☄️hip☄️
Isoniazid…hydralazine…procainamide
Phase 2 methylation?
Noradrenaline
Phase2 glycine?
Aspirin
Phase 2 sulfation?
Steroids
Basic drugs ?
Ephidrine….amphetamine
Acidic drugs,?
Aspirin ….barbiturate
Increase rate of gastric empyting ?
Metoclopramide
Decrease rate of gastric empyting ?
Atropine
1- Rapid disintegration?
2- slow disintegration,?
1- paracetamol
2-digoxin
Hepatic first pass?
Pass through liver and distructed via enzymes….(mlpnn)
Morphine …nitroglycrine…lidocaine…propranolol…natural sex hormone
Hepatic enzymes inducers
Phenobarbitone
Phenytoin
Carbamazepine
Rifampicin
Androgen
Tobacco smoke
hepatic enzymes inhibitors specific
Cimetidine
Ciprofloxacin
Chloramphenicol
Erythromycin
Estrogen
Valproic acid
Hepatic enzymes inhibitors non-specific?
hepatotoxic drugs &drugs decreasing hepatic blood flow
as propranolol & cimetidine
Cause absent limbs (phocomelia)
thalidomide