Gene Therapy (Genes In Complex Retrovirus)

Question 1

vif

Answer 1

Promote infectivity of cell-free viruses

Question 2

vpr

Answer 2

Nucleocytoplasmic shutting of reg proteins

Question 3

vpu

Answer 3

Required for efficient virion budding

Question 4

nef

Answer 4

Host cell apoptosis enhancing infectivity

Question 5

rev

Answer 5

Regulator of structural gene expression

Question 6

tat

Answer 6

Potent transcriptional activator

Question 7

gag

Answer 7

Responsible for the production of core proteins

Question 8

pol

Answer 8

Responsible for viral replication and integration
RT, IN, PR, RNase (viral enzymes)

Question 9

env

Answer 9

Responsible for the production of envelope proteins
Mediated CD4 binding and membrane fusion

Question 10

What are the two basic amino acids abundant in histones

Answer 10

Arginine and Lysine

Question 11

Basic structure of histone is

Answer 11

Nucleosome

Question 12

What are the major types of histones

Answer 12

H1, H2A , H2B , H3, H4

Question 13

Functions of telomeres

Answer 13

Plays critical role in chromosome replication and maintenance
Also plays crucial role in replication of the ends of linear DNA

Question 14

Function of telomerase

Answer 14

Uses RT activity to replicate telomeric DNA sequences