Gene Discovery Flashcards
1
Q
Polytene chromosomes
A
2
Q
RFLPs
A
Restriction fragment length polymorphisms
3
Q
Microsatelllites
A
DNA repeats that vary in length
4
Q
LOD score
A
- Calculate the likelihood of observing the genotype data if there is linkage to the trait
- Calculate the likelihood of observing the genotype data if there is no linkage to the trait
- LOD (log of the odds) score = log of the ratio of these two likelihoods
5
Q
Bonferroni correction
A
6
Q
For GWAS, P values should be ____ or lower to be considered genome-wide significant
A
For GWAS, P values should be ~ 5x10-8 or lower to be considered genome-wide significant
7
Q
For polygenic disease, nearly all OR are ____.
A
For polygenic disease, nearly all OR are < 3 and > 0.33
8
Q
Allelic odds ratio
A
