Gene delivery Flashcards
1
Q
Three main applications of gene delivery
A
2
Q
Advantages of viral vectors
A
high gene delivery efficiency
3
Q
Disadvantages of viral vectors
A
immune response
insertional mutagenesis
lack of specificity
4
Q
Advantages of non-viral vectors
A
safer than viral systems
easy to modify
5
Q
Disadvantages of non-viral vectors
A
much less efficient gene delivery
either high transfection efficiency with high toxicity or low efficiency with safety
6
Q
Cationic lipids
A
cationic head group
lipid moiety
lipofectin: DOTMA
DOPE
