Gen MOA

Question 1

Tenapanor

Answer 1

NHE3 Transport inhibitor
(IBS-C)

Question 2

Tegaserod

Answer 2

5-HT4 agonist/ activator of GI motility (IBS-C [women under 65])

Question 3

Prucalopride

Answer 3

5-HT4 agonist–>stimulates AC release–>longitudinal muscle contraction.

Question 4

Lubiprostone

Answer 4

Activates chloride chanel (CLC-2 [9 total CLC’s])–>Cl into lumen, Nacogdoches follows

Question 5

Plecanatide

Answer 5

Guanylate cyclase-C agonist–>increases intra & extracellular levels of guanosine monophospate (cGMP)–> secretion of Cl- and bicarbonate into lumen.