Gen Derm Flashcards
What two types of amyloidosis are AL (light chain typically gamma) derived?
Nodular amyloidosis
Primary systemic amyloidosis
What protein derivation is secondary systemic amyloidosis?
AA (non-immunoglobulin protein; amyloid associated)
What protein is hemodialysis associated amyloidosis derived?
Beta 2 micro globulin
What two types of systemic amyloidosis are derived from protein TTR (transthyretin)?
Senile systemic amyloidosis
Familial amyloidosis
What 3 periodic fever syndromes contribute or can cause secondary systemic amyloidosis?
Muckle wells
Familial Mediterranean fever
TRAPS (TNF receptor associated periodic syndrome)
What 3 cutaneous amyloidosis are keratinocyte derived?
Macular amyloidosis
Lichen amyloidosis
Secondary cutaneous amyloidosis
Porphyrins light at what wavelength?
400-410nm
Enzyme deficiency in congenital erythropoietic porphyria
UPS : uroporphyrinogen III co synthase
Erythropoietic proto porphyria (EPP) enzyme deficiency?
Ferrochelatase
Porphyria cutanea tarda (PCT) deficiency enzyme?
Uroporphyrinogen decarboxylase (UD)
Enzyme deficiency Acute intermittent porphyria?
Porphobilinogen deaminase
Enzyme deficiency Variegate porphyria?
Protoporphyrinogen oxidase (PPO)
Enzyme deficiency of hereditary coproporphyria?
Coproporphyrinogen oxidase (CPO)
Enzyme deficiency in Hepatoerythropoietic porphyria?
Uroporphyrinogen decarboxylase (UD)
Two names for Type 1 familial hyperlipidemia
Familial LPL deficiency
Familial hyperchylimicronemia
Defect in type 1 hyperlipidemia
Decrease lipoprotein lipase or apoprotein CII defect
What labs are increased in type 1 hyperlipidemia
Increase TG (chylomicrons)
What clinical findings in type 1 hyperlipidemia?
Eruptive xanthomas
Acute pancreatitis
Abd pain
Lipemia retinalis
What crystals are seen in gout?
Needle like crystals of mono sodium urate
What happens to gout crystals under polarized light?
Negative birefringence
Yellow parallel to red filter
What crystals are seen in pseudogout?
Calcium pyrophosphate dihydrate (CPPD) crystals within joints
Rhomboid shape
What happens to pseudogout crystals under polarized light?
Weakly positive birefringence
Blue when parallel to red filter
Most common cosmetic preservative to cause ACD.
Quarternium-15
What rubber accelerator is found in rubber shoes, gloves, elastic, fungicides
Thiuram
Thiuram reacts with what?
Disulfram
Most common allergic shoe dermatitis
Mercaptobenzothiazole (MBT)
What is the rubber component in elastic undergarments that when washed with hypochlorite causes more allergenic and results in elastic dermatitis or “bleached rubber syndrome”
Carba mix or carbamates
What textile mix causes purpuric contact dermatitis when clothes fits tightly
Ethylene urea melamine formaldehyde mix
Fast acting adhesive found in super or Krazy glue, liquid bandages, and dermabond
Cyanoacrylate
Artificial nails (adhesive)
Ethyl acrylate
Artificial nails, dental fillings/sealants, glue or bone cement for artificial joints
Methacrylate
What adhesive commonly seen in dentist orthopedic surgeon may diffuse through intact surgical glove and cause paresthesias
Methacrylate
Contact allergen in sunscreen blocking UVB
PABA (padimate O)
Contact allergen in sunscreen blocking UVA
Oxybenzone
PABA cross reacts with what 4 substances or meds
Sulfonamides
Azo dyes
Benzocaine
PPD
What is the most common sunscreen agent to cause photo allergic contact dermatitis
Oxybenzone
What 3 steroids are in group A?
Hydrocortisone acetate
Prednisone
Methylprednisolone
What 5 corticosteroids are found in group B?
Triamcinolone acetonide Desonide Fluocinolone acetonide Fluocinonide Halcinonide
What 3 steroids are in group D?
Hydrocortisone-17-vale rate/butyrate
Clobetasol-17-butyrate
Clobetasol propionate
Betamethasone valerate/diproprionate
What contact allergen is in group A steroids?
Tixocortol-21-pivalate
What contact allergen is used in group B steroids?
Budesonide (also used in some group D steroids)
What contact allergen for group D steroids?
Hydrocortisone-17-butyrate
What allergen is found in permanent hair dye, black henna, temporary tattoos, photographic developer
PPD (paraphenylenediamine)
“Permanent pilar dye”
Schnitzler’s syndrome
Urticarial vasculitis & monoclonal IgM gammopathy & at least 2 of following: fever, arthralgias, ESR, WBC, bone abnormality, bone pain
