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sima jain > Gen Derm > Flashcards

Gen Derm Flashcards

1
Q

What two types of amyloidosis are AL (light chain typically gamma) derived?

A

Nodular amyloidosis

Primary systemic amyloidosis

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2
Q

What protein derivation is secondary systemic amyloidosis?

A

AA (non-immunoglobulin protein; amyloid associated)

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3
Q

What protein is hemodialysis associated amyloidosis derived?

A

Beta 2 micro globulin

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4
Q

What two types of systemic amyloidosis are derived from protein TTR (transthyretin)?

A

Senile systemic amyloidosis

Familial amyloidosis

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5
Q

What 3 periodic fever syndromes contribute or can cause secondary systemic amyloidosis?

A

Muckle wells
Familial Mediterranean fever
TRAPS (TNF receptor associated periodic syndrome)

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6
Q

What 3 cutaneous amyloidosis are keratinocyte derived?

A

Macular amyloidosis
Lichen amyloidosis
Secondary cutaneous amyloidosis

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7
Q

Porphyrins light at what wavelength?

A

400-410nm

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8
Q

Enzyme deficiency in congenital erythropoietic porphyria

A

UPS : uroporphyrinogen III co synthase

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9
Q

Erythropoietic proto porphyria (EPP) enzyme deficiency?

A

Ferrochelatase

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10
Q

Porphyria cutanea tarda (PCT) deficiency enzyme?

A

Uroporphyrinogen decarboxylase (UD)

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11
Q

Enzyme deficiency Acute intermittent porphyria?

A

Porphobilinogen deaminase

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12
Q

Enzyme deficiency Variegate porphyria?

A

Protoporphyrinogen oxidase (PPO)

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13
Q

Enzyme deficiency of hereditary coproporphyria?

A

Coproporphyrinogen oxidase (CPO)

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14
Q

Enzyme deficiency in Hepatoerythropoietic porphyria?

A

Uroporphyrinogen decarboxylase (UD)

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15
Q

Two names for Type 1 familial hyperlipidemia

A

Familial LPL deficiency

Familial hyperchylimicronemia

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16
Q

Defect in type 1 hyperlipidemia

A

Decrease lipoprotein lipase or apoprotein CII defect

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17
Q

What labs are increased in type 1 hyperlipidemia

A

Increase TG (chylomicrons)

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18
Q

What clinical findings in type 1 hyperlipidemia?

A

Eruptive xanthomas
Acute pancreatitis
Abd pain
Lipemia retinalis

19
Q

What crystals are seen in gout?

A

Needle like crystals of mono sodium urate

20
Q

What happens to gout crystals under polarized light?

A

Negative birefringence

Yellow parallel to red filter

21
Q

What crystals are seen in pseudogout?

A

Calcium pyrophosphate dihydrate (CPPD) crystals within joints
Rhomboid shape

22
Q

What happens to pseudogout crystals under polarized light?

A

Weakly positive birefringence

Blue when parallel to red filter

23
Q

Most common cosmetic preservative to cause ACD.

A

Quarternium-15

24
Q

What rubber accelerator is found in rubber shoes, gloves, elastic, fungicides

25
Q

Thiuram reacts with what?

26
Q

Most common allergic shoe dermatitis

A

Mercaptobenzothiazole (MBT)

27
Q

What is the rubber component in elastic undergarments that when washed with hypochlorite causes more allergenic and results in elastic dermatitis or “bleached rubber syndrome”

A

Carba mix or carbamates

28
Q

What textile mix causes purpuric contact dermatitis when clothes fits tightly

A

Ethylene urea melamine formaldehyde mix

29
Q

Fast acting adhesive found in super or Krazy glue, liquid bandages, and dermabond

A

Cyanoacrylate

30
Q

Artificial nails (adhesive)

A

Ethyl acrylate

31
Q

Artificial nails, dental fillings/sealants, glue or bone cement for artificial joints

A

Methacrylate

32
Q

What adhesive commonly seen in dentist orthopedic surgeon may diffuse through intact surgical glove and cause paresthesias

A

Methacrylate

33
Q

Contact allergen in sunscreen blocking UVB

A

PABA (padimate O)

34
Q

Contact allergen in sunscreen blocking UVA

A

Oxybenzone

35
Q

PABA cross reacts with what 4 substances or meds

A

Sulfonamides
Azo dyes
Benzocaine
PPD

36
Q

What is the most common sunscreen agent to cause photo allergic contact dermatitis

A

Oxybenzone

37
Q

What 3 steroids are in group A?

A

Hydrocortisone acetate
Prednisone
Methylprednisolone

38
Q

What 5 corticosteroids are found in group B?

A 
Triamcinolone acetonide
Desonide
Fluocinolone acetonide
Fluocinonide
Halcinonide
39
Q

What 3 steroids are in group D?

A

Hydrocortisone-17-vale rate/butyrate
Clobetasol-17-butyrate
Clobetasol propionate
Betamethasone valerate/diproprionate

40
Q

What contact allergen is in group A steroids?

A

Tixocortol-21-pivalate

41
Q

What contact allergen is used in group B steroids?

A

Budesonide (also used in some group D steroids)

42
Q

What contact allergen for group D steroids?

A

Hydrocortisone-17-butyrate

43
Q

What allergen is found in permanent hair dye, black henna, temporary tattoos, photographic developer

A

PPD (paraphenylenediamine)

“Permanent pilar dye”

44
Q

Schnitzler’s syndrome

A

Urticarial vasculitis & monoclonal IgM gammopathy & at least 2 of following: fever, arthralgias, ESR, WBC, bone abnormality, bone pain

sima jain (1 decks)

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