GBS, MG

Question 1

AIDP

Answer 1

Acute Inflammatory Demyelinating Polyneuropahty

Question 2

Hx features

Answer 2

antecedent infection

Question 3

in GBS, weakness is

Answer 3

progressive, rel symmetrical
ascending

bulbar weakness, ataxia, resp muscle dysfunction may predominate

Question 4

Sensory deficits in GBS

Answer 4

minimal

Question 5

Sensorium in GBS

Answer 5

Normal

Question 6

Reflexes in GBS

Answer 6

HYPO or AREFLEXIA

Question 7

Facial diplegia in GBS

Answer 7

YES

Question 8

CSF in GBS

Answer 8

albumino-cytologic dissociation (high protein, low WBC <10)

Question 9

EMG in GBS

Answer 9

prolonged F waves

DECR neve conduction velocity or conduction BLOCK

Question 10

Mgt of GBS

Answer 10

plasmapheresis or IVIG
ventilate if necessary
monitor cardiac rhythm and hypotension

Question 11

presenting Sx in MG

Answer 11

50-60% diplopia, ptosis

Question 12

most serious complication of MG

Answer 12

also respiratory muscle weakness

Question 13

Dx in MG

Answer 13

Tensilon (Edrophonium) test (Sn 90%)

AChR antibodies - Sn 90 Sp 100

RNS Sn 50
SFEMG Sn 90

Question 14

Tx in MG

Answer 14

Acetylcholinesterase inhibtors
- reversibly binds to AchE

eg. Pyridostigmine
onset 15-30 min peaks 1-2 wears off 3-4

Question 15

Other Tx in MG

Answer 15

IVIG, plasmapheresis
STEROIDS - imp seen in 2 weeks; with mild exacerbation 1-17 days after
Thymectomy

Question 16

Steroids induce effective remission in up to

Answer 16

80% of patients