Gastroenterology Flashcards
Antibiotics used for prophylaxis in variceal UGIB
Broad spectrum, to cover SBP, ofer quinolones in people with cirrhosis
Management of variceal upper GI bleed
1) A-E and escalation status!
A, B
C: Examination, IV access X 2, bloods (G&S, coag, VBG, FBC, U&E, LFT)
Fluids / blood transfusion if needed
patient needs to be stable before endoscopy
2) Review medications
Stop NSAIDs, anticoagulant, antiplatelets, antihypertensives, clopidogrel, reverse if can
3) Correct coagulopathy - ?FFP, vit K, platelets
4) Antibiotics - prophylaxis in cirrhosis against SBP (b4 endoscopy)
5) Terlipressin - splanchnic vasoconstriction, reduce portal pressures, reduce bleeding (b4 endoscopy)
6) Endoscopy - are they fit? can they lie for 15 mins? Glasgow blatchford score.
- Band, glue
7) NBM, fluid balance, stool chart
not work
Sengstaken blakemore tube
Interventional radiology - CT + embolisation
Surgery
TIPS (transjugular intrahepatic porto-systemic shunt) connects hepatic vein to portal vein
Prophylaxis of UGIB in varices
1) Propranolol
2) Endoscopic variceal ligation
For medium- large varices,
every 2 weeks until eradicated, give prophylactic PPI as well to endoscopic variceal ligation induced ulcers
3) Tranjugular intrahepatic portosystemic shunt (TIPS)
Assessment of severity of UGIB
1) Pre-endoscopy = Glasgow blatchford = need for endoscopy
2) Post-endoscopy = rockall = mortality post endoscopy
Antibiotic prophylaxis in variceal upper GI bleeds
broad spectrum antibiotics, often quinolone
give for 5-7 days
Terlipressin in variceal upper GI bleeds
1) Give 2mg QDS for 3-5 days or until definitive endoscopic haemostasis achieved
reduces portal pressure and helps control haemorrhage
75mg aspirin in UGIB - what to do
can continue!
Heparin reversal in UGIB
dose timing
Give protamine
8 hrs before = half the dose
Warfarin reversal in UGIB
Give PCC and IV vitamin K if actively bleeding
If stable, give vitamin K IV
endoscopy - what’s done in variceal management
- band ligation
- gastric = intravariceal injection of N-butyl-2-cyanoacrylate glue.
non variceal endoscopy management
- Clips + adrenaline
- Thermal coagulation + adrenaline
-fibrin/ thrombin injection + adrenaline
Alternative to UGIB if endoscopy doesn’t work
1) Sengstaken blakemore tube
2) Interventional radiology - CT + embolisation
3) Surgery - tie off artery
Who needs re-scoping after UGIB?
Bleeding due to
1) Varices
2) PUD - in 6-8 weeks, to ensure resolution and no underlying carcinoma
How long NBM for post endoscopy?
over night - may need further endoscopy, especially if concern about haemostasis
When to offer platelet transfusion in upper GI bleed patients?
Actively bleeding AND platelets < 50 x 10^9
if not actively bleeding AND stable - don’t offer
Who give fresh frozen plasma to?
Actively bleeding and INR / activated partial thromboplastin > 1.5 times normal
If fibrinogen level remains less than 1.5 g/litre despite fresh frozen plasma use, offer cryoprecipitate as well
Coagulopathy correction in UGIB
1) Platelets if platelet < 50 AND actively bleeding
2) INR > 1.5 or activated partial thrombplastin time ratio > 1.5 = give fresh frozen plasma
If INR > 1.5 and on warfarin, give PCC and vit K!
3) Fibrinogen < 1.5 = fresh frozen plasma -> if still low despite FFP, give cryoprecipitate
Refeeding syndrome - electrolyte disturbances
phosphate
potassium
magnesium
thiamine
calcium
sodium
Symptoms of re-feeding syndrome
1) No ATP = muscle cannot contract = myocardium cannot (heart failure) diaphragm cannot (respiratory failure)
2) Low calcium and K+: Cardiac: Arrhythmia
3) Neurological: Weakness, paresthesia, tetany, seizure
4) low thiamine: Wernicke encephalopathy
5) Peripheral oedema
5) Low phosphate - low ATP in muscles = can cause rhabdomyolysis
