Gastroenterology Flashcards

1
Q

What are the different causes of abdominal pain?

A

Medical
Surgical
Functional

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2
Q

What are the medical causes of abdominal pain?

A
Constipation- don't forget!
UTI
IBD
IBS
Coeliac
Pyelonephritis
In adolescent girls-
Dysmenorrhoea
Mittelschmerz 
Ovarian torsion
PID
Pregnancy
Ectopic pregnancy
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3
Q

What are the surgical causes of abdominal pain?

A

Testicular torsion- sudden onset, one sided, N+V
Bowel obstruction- Absolute constipation, vomiting, abdominal pain, abdominal distension
Appendicitis- Generalised then RIF
Intussusception- Red jelly like stools, non specific, colicky pain

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4
Q

What are the functional causes of abdominal pain?

A

Very common in >5yrs old
Get recurrent abdominal pain, without a physical cause.
Pt not making it up but could be in response to psychological stress.

Can overlap with abdominal migraine.

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5
Q

How is functional abdominal pain managed?

A

Encourage distraction activities for the child
Educate parents to not remind or ask the child about the pain
Find stressors and better manage them
Avoid NSAIDs
Encourage good sleep, healthy meals, exercise, hydration
Inform school counsellor

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6
Q

What are the Red Flags for abdominal pain?

How do you investigate abdominal pain?

A
Red Flags-
Persistent or bilious vomiting
Chronic severe diarrhoea
Wt loss
Fever
Rectal bleeding
Dysphagia
Ab pain
Night time pain
Investigations-
Anaemia- IBD, Coeliac
Raised CRP/ESR- IBD
Raised Faecal Calprotectin- IBD
Urine dip- UTI
Raised Anti-TTG or Anti-EMA- Coeliacs
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7
Q

What is an abdominal migraine?

How is it managed?

A

Episodes of central abdominal pain lasting an hour. Common in children, may develop migraine in adulthood.
May be associated with N+V, anorexia, pallor, headache, aura, photophobia.

Manage acute-
Dark quiet room
Ibuprofen
Paracetamol
Sumatriptan

Prevention-
Commonly use Pizotifen. But withdraw slowly due to withdrawal effects of anxiety, depression, poor sleep and tremor.

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8
Q

What are the causes of constipation?

A
Commonly it is primary where the cause is functional/idiopathic.
Can also have secondary causes:
Hirschsprung's 
Cystic Fibrosis
Hypothyroidism
Sexual abuse
Anal stenosis
CMPI
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9
Q

What are the features of constipation?

A
Stools <3x week
Rabbit dropping
Overflow/soiling
Abdominal pain
Hard stools
Rectal bleeding with difficult stools
Stool felt in abdomen
Retentive posturing- i.e. in a way to stop the stools
Straining and painful to pass stools
Reduced sensation in needing to open the bowel
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10
Q

What is encopresis?

A

Refers to faecal incontinence.
Not normal after 4yrs old.
There has been chronic constipation so the hard impacted stool have stretched the rectum, leading to desensitisation. Hard stools will remain impacted, whilst smaller will pass by and leak out.

Causes include:
Herschsprungs
Spina bifida
Learning disability
Cerebral palsy
Abuse
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11
Q

Which lifestyle factors can influence constipation?

A
Low fibre diet
Dehydration
Sedentary lifestyle
Habitually not opening bowels
Psychological stressors- consider safeguarding
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12
Q

What is desensitisation of the rectum?

A

Pt has a habit of holding in stool or not reacting to full sensation of rectum
Over time loses sensation of rectal fullness so open bowel less frequently
More stool accumulates- faecal impaction
Rectum stretches
Leads to further desensitisation of the rectum

The longer this continues the more difficult it becomes to treat and reverse the constipation.

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13
Q

What are red flags of constipation?

A

Not passing meconium within first 24-48hrs of life- HS, CF
Ribbon like stool- Anal stenosis
Abnormal anus- Anal stenosis, Sexual abuse
Neurological i.e. lower limbs affected- Cerebral palsy, spinal cord lesion
Vomiting- HS, bowel obstruction
Failure to thrive- Coeliac, hypothyroidism, safeguarding
Acute abdominal pain and bloating- Intussusception or bowel obstruction

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14
Q

What are the complications of constipation?

A
Pain
Anal fissure
Haemorrhoids
Reduced sensation
Overflow/soiling
Psychological morbidity
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15
Q

How is constipation managed?

A

It is possible to diagnose functional/idiopathic constipation without investigation, as long as red flags have been considered. Educate parents/pt that treatment is a long process

Manage reversible factors i.e. increase fibre intake, increase water intake
First line laxative is Movicol.
If faecal impaction then disimpaction regimen with high dose laxatives
Encourage toilet trips, star charts, bowel diary
Wean off laxatives slowly one normal bowel habits have been established.

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16
Q

What are the differentials of vomiting?

A
Overfeeding
GORD
Gastroenteritis
Other infections i.e. meningitis, tonsillitis, UTI
Pyloric stenosis
Intestinal obstruction
Bulimia
Appendicitis
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17
Q

How does GORD present?

A

Babies don’t fully develop their LOS until 1 yrs old so reflux is common amongst most <1yrs. Considered normal as long as baby’s growth is unaffected and they are otherwise well.

GORD-
Hoarse cry
Chronic cough
Distressed after feeding
Reluctant to feed
Poor weight gain
Pneumonia

> 1yrs can present similar to adults with a night cough, acid reflux and retrosternal pain.

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18
Q

How is GORD managed?

A
Encourage:
Small regular feeds
Avoid overfeeding
Sit upright after feed
Burping regularly to help settle milk

Gaviscon- coats the milk in the stomach to stop it from coming back up
Thickened milk/thickener
Ranitidine
Lansoprazole

Rarely may need to investigate with a barium swallow and endoscopy

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19
Q

What are the red flags which could suggest underlying pathology of reflux?

A

Haematemesis/melaena- peptic ulcer, varices
Fresh rectal bleeding- CMPA,
Projectile vomiting- Bowel obstruction, pyloric stenosis
Inability to keep food down- Bowel obstruction, pyloric stenosis
Rash, angioedema- CMPA
Respiratory symptoms- Aspiration, infection
Reduced consciousness, bulging fontanelles- meningitis
Bile stained vomit- Bowel obstruction
Abdominal distension- Bowel obstruction

Apnoea is very serious and needs immediate investigations.

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20
Q

What is Sandifer’s syndrome?

A

Reflux with associated torticollis and dystonia.
Will resolve itself.
Needs investigating to rule out more serious epilepsy.

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21
Q

What is pyloric stenosis?

A

Hypertrophy of the pyloric sphincter of the stomach, leading to obstruction. After feeding there is increased peristalsis of the stomach, but since the food can’t move to the duodenum it is forced out of the oesophagus- projectile vomiting.

Presents within first few wks of life with thin, hungry baby who is failing to thrive.

22
Q

How is pyloric stenosis investigated and managed?

A

Abdomen can feel a hard ‘olive sized’ mass- hypertrophic pyloric sphincter.
Blood gas will show hypochloric metabolic alkalosis (vomit stomach HCl)
USS of abdomen to see a hypertrophic pyloric sphincter

Managed with laparoscopic pyloromyotomy- remove part of the SM of the PS- very good prognosis.

23
Q

What are the signs and symptoms of Appendicitis? (RECAP)

A
Central pain which becomes RIF
McBurneys point tenderness (1/3 distance from ASIS to umbilicus)
Loss of appetite
N+V
Rebound tenderness (suggesting rupture)
Rovsings sign- palpae in LIF will cause pain in RIF
Gurading
Percussion tenderness
24
Q

What are the key differentials for appendicitis? (RECAP)

A

Ectopic pregnancy
Ruptured/torsion of ovarian cyst
Meckels diverticulum- can cause volvulus or intussusception, if ruptured of inflamed
Mesenteric adenitis- inflamed abdominal LN often associated with tonsillitis or URTI

25
Q

How is appendicitis managed in children?

What are the complications?

A

Need appendicectomy.
If <10yrs need to be under paediatric surgeon.
>10yrs can be under adult surgeons provided there is a paediatric unit.

Post surgery complications include-
Bleeding
Infection
Pain 
Scars
Damage to surrounding organs
Removal of normal appendix
VTE
26
Q

What is intussusception?

How does a patient present?

A

Part of the bowel telescopes/invaginates into another part of bowel. This makes the bowel wall appear thicker and the lumen more narrow so stool will not be able to pass through the bowel.
Common in 6 months to 2yrs old.

Presentation-
Redcurrent jelly like stool
Non specific colicky abdominal pain
RUQ sausage shaped mass (stool)
Vomiting 
Intestinal obstruction
May have had a recent viral infection I.e. URTI
27
Q

What is intussusception often associated with?

A
Concurrent viral infection
Henoch 
Cystic fibrosis 
Intestinal polyps
Meckels diveritculum
28
Q

How is intussusception investigated?

How is intussusception managed?

A

Investigate with USS or contrast enema.

Management-
Need to reduce intussusception.
Either therapeutic enema I.e. water, contrast or air is forced up the colon to force the bowel to move out of itself.
If this fails then surgical repositioning.

If the blood supply is compromised and leads to gangrenous bowel, or there is a bowel perforation then need surgical resection.

29
Q

What are the complications of intussusception?

A

Bowel perforation
Bowel gangrenous
Death
Bowel obstruction

30
Q

What is the pathophysiology of Hirschsprung’s?

A

Normal bowel has myenteric plexus, which controls the peristalsis. During normal development the parasympathetic cells travel distally down the GI tract. In Hirschsprung’s these parasympathetic cells don’t travel completely down and so part of the colon and rectum are left without parasympathetic innervation. If the entire colon is affected this is total colonic aganglionosis.

Bowel without parasympathetic cannot relax therefore in a state of constriction. Stool can’t get past, and so proximal to this constriction get stool collection and bowel dilation.

31
Q

What are the associations with Hirschsprung’s?

A

Usually stand alone.
Strong FHx.

Can be associated with Downs, neurofibromatosis and MEN II.

32
Q

How does Hirschsprung’s present?

A

Some neonates born with bowel obstruction.

Features-
Don’t pass meconium within first 24-48hrs
Vomiting
Distended abdomen 
Chronic constipation since birth 
Poor growth and failure to thrive
33
Q

How is Hirschsprung’s investigated?

How is Hirschsprung’s managed?

A

Diagnosed with a rectal biopsy- will show absence of ganglionic cells.
Can also use and X-ray to look for obstruction or features of HAEC

Manage with bowel resection. Will go on to live normal lives but have life long bowel function disturbances and some may have incontinence issues.

34
Q

What is HAEC?

How is it managed?

A

Hirschsprung’s associate enterocolitis.
Inflammation of the bowel, in a pt with Hirschsprung’s. This leads to fever, abdominal distension, diarrhoea (often bloody) and sepsis features. This can lead to toxic mega colon and perforation.

Investigate with X-ray.

Manage with fluids, Abx, decompression surgery.

35
Q

What are the signs of bowel obstruction? (RECAP)

A

Abdominal distension
Abdominal pain
Vomiting
Absolute constipation

Also hear tinkling bowel sounds early on which become absent later

36
Q

What are some causes of bowel obstruction?

A
Hirschsprung’s 
Intussusception 
Oesophageal atresia
Meconium ileus
Imperforate anus
37
Q

How is bowel obstruction investigated?

How is bowel obstruction managed?

A

Investigated with an AXR- dilated loops of bowel proximal to the obstruction, collapsed loops of bowel distal to the obstruction. Absence of air in the rectum.

Manage by paediatric surgical unit admission. Suck and drip- insert NG tube to ‘suck out’ from the bowel, give IV fluids.

38
Q

What is biliary atresia?

A

Bile duct is either narrowed partially or completely; the bile can not be excreted out of the liver. Usually conjugated bilirubin from the liver is excreted in the bile, so this leads to a build up of conjugated bilirubin.

39
Q

How is biliary atresia investigated?

How is biliary atresia managed?

A

Suspect if >14 days jaundice in term baby or >21 days jaundice in premature baby.
Measure the proportion of conjugated bilirubin compared to unconjugated. Higher conjugated suggests biliary atresia.

Management is surgery. Kasai portoenterostomy- take part of the small intestine and insert it onto the liver where the bile duct would usually attached. It is effective but many patients will go on to need full liver transplant.

40
Q

What are the extra-intestinal manifestations of IBD?

A
Clubbing
Episcleritis and iritis
Inflammatory arthritis
Erythema nodusum 
Pyoderma gangrenosum 

UC- ascending cholangitis (check LFTs)

41
Q

How is IBD investigated?

A

FBC (anaemia, thrombocytosis as a sign of inflammation), LFTs (albumin as nutrition marker, AC), CRP, TFTs, U+Es.
Faecal calprotectin.

Gold standard is an OGD and colonoscopy in children to get the most information.
Can further image with USS, CT or MRI

42
Q

How is Crohns managed in children?

A

Inducing remission-
First line is by a full liquid diet for minimum of 6 wks to reverse the acute flare.
This is the best method and should always be trialled before steroids.
2nd line by a long way is steroids I.e. IV hydrocortisone or oral prednisolone.
3rd line would be immunosuppressants I.e. azathioprine.

Maintaining remission-
Azathioprine
Methotrexate
Mercaptopurine

Surgery to manage strictures and fistulas. Since Crohns contains skip lesions, surgical resection is only effective if the distal ileum alone is affected.

43
Q

How is UC managed in children?

A

Inducing remission-
First line is mesalazine (aminosalicylate)
Second line is corticosteroid.

In more severe disease first line is corticosteroid, second line is IV ciclosporin.

Maintaining remission-
Mesalazine
Azathioprine

Surgery-
Can remove the entire rectum and colon- create an ileostomy or j-bag for the stool to leave. J bag involves using the ileum to act as a rectum.

44
Q

What is coeliacs disease?

What diseases is it associated with?

A

Exposure to gluten causes inflammation of the small intestine, particularly the jejune. This leads to villous atrophy and crypt hypertrophy.

The antibodies involved are IgA antibodies Anti-TTG and Anti-EMA. Thought HLA-DHQ 2 gene (mainly) and DHQ-8 are also involved.

Associated with-
T1DM
Thyroid disease
Autoimmune hepatitis 
Down’s syndrome
45
Q

How does coeliacs disease present?

A
Asymptomatic
Or
Fatigue
Wt loss
Mouth ulcers
Failure to thrive (young children) 
Diarrhoea 
Anaemia due to deficiency or iron, B12 or folate
Dermatitis herpatiformis

Rarely can get neurological features-
Cerebellar ataxia
Peripheral neuropathy
Epilepsy

46
Q

How is coeliacs diagnosed?

A

Need to still be on a gluten diet.
Test total IgA levels.
Test with anti-TTG, anti-EMA and HLA type.
Anti-TTG and anti-EMA are IgA; some patients can have IgA deficiency so will have negative coeliacs test even though they are positive. Test for the IgG levels of these antibodies.

Can also conduct endoscopy with biopsy.

ALWAYS TEST PATIENTS DIAGNOSED WITH T1DM EVEN IF THEY DON’T HAVE SYMPTOMS.

47
Q

How is coeliacs managed?

A

Gluten free diet life long.

48
Q

What are the complications of coeliacs?

A
Anaemia 
Vitamin deficiency
Osteoporosis 
Ulcerative jejunitis 
Non Hodgkin lymphoma
49
Q

What is gastroenteritis?

How is it managed?

A

Inflammation of the stomach and intestines leading to nausea, vomiting and diarrhoea.
Will self resolve.
Need to ensure patient is not dehydrated. Encourage oral fluids, but if not tolerated and dehydrated then IV fluids.
Anti diarrhoeal and antibiotics are not indicated.
Child should not go school fro 48hrs, on wards should be isolated.
Commonly caused by virus- contagious.

50
Q

What are the complications of gastroenteritis?

A

Lactose intolerance
IBS
GBS
Reactive arthritis