Gastritis Flashcards
What are the causes of acute gastritis?
Mucosal damage results in increased permeability
Acid diffuses back into the mucosa to cause gastritis
Epithelial cells necrose and cause erosions (hematemesis)
What are the clinical signs of acute gastritis?
Vomiting Lethargy Depression Polydipsia Hematemesis Cranial abdominal pain
What are differential diagnoses for acute gastritis?
Foreign body (obstruction)
Acute pancreatitis
Infectious disease
Systemic disease
How do you diagnose acute gastritis?
History and PE
Abdominal radiographs
Biochemical tests
Response to therapy
Need to exclude other diseases
How do you treat acute gastritis?
Rest GI
Supportive care
Feed a bland diet
What is most effective for acute self-limiting vomiting?
Brief fasting (12-24 hours)
What causes chronic gastritis?
Inflammatory (Lymphoplasmacytic or eosiniphilic)
Food responsive disease
Reflux (Bilious vomiting syndrome)
Helicobacter?
What are the clinical signs of chronic gastritis?
Vomiting
Hematemesis
Appetite changes
How do you treat chronic gastritis?
Mild disease: diet trials (hypoallergenic), acid reducer (omeprazole), prokinetic (cisapride/metaclopramide)
Moderate to severe disease: prednisone, azathioprine, chlorambucil
How do you diagnose chronic gastritis?
Exclude other causes (parasites, tumors, FRD)
Biopsy
What is helicobacter gastritis?
Causes lymphoid hyperplasia
May be associated with chronic vomiting
Diagnose with Warthin-Starry (silver) stain on biopsy
What causes gastric ulcers?
Ulcerogenic drugs (steroids, NSAIDs) Liver disease Tumors Protein-calorie malnutirtion Uremia Stress
What is reflux gastritis/bilious vomiting syndrome?
Defect in pyloric function or gastric motility allows prolonged contact of bile with mucosa -> damage
Vomit bile-stained mucus/fresh blood in early morning
Treatment- increase feeding frequency + prokinetic, H2 receptor antagonist, H+ pump inhibitor
How do you treat gastric ulcers?
Eliminate underlying cause PPI's (omeprazole) Sucralfate Blood transfusion Endoscopy Surgery
What causes gastric outlet obstruction?
GDV
Foreign bodies
Congenital stenosis (pyloric hypertrophy)
Acquired stenosis