Gastric Cancer Flashcards
Most common histopathology of gastric cancer
Adenocarcinoma
3 RFs for gastric cancer
Diets rich in Nitrates/ Salts
H. pylori
Smoking
3 Sx at early stages of gastric cancer
Often asymptomatic
Loss of appetite
Nausea
3 general signs of late gastric cancer
Weight loss
Signs of IDA
Palpable epigastric tumour
4 Sx of gastric outlet obstruction
Dysphagia
Abdo pain
Early satiety
Vomiting
2 signs of upper GI bleeding
Haematemesis
Melena
2 signs of metastatic disease in gastric cancer
Hepatomegaly
Ascites
4 masses that indicate metastatic disease in gastric cancer
Left supraclavicular adenopathy (Virchow node)
Umbilical nodule (Sister Mary Joseph)
Mass on DRE (Blumer shelf)
Ovarian mass (Krukenberg tumour)
2 paraneoplastic syndromes possible in gastric cancer
Leser-Trelat sign (sudden onset multiple Seb K’s)
Acanthosis nigricans
Ix for gastric cancer
Upper gastrointestinal endoscopy with biopsy
Bloods for IDA
CT TAP
Surgical tx for gastric cancer
Total gastrectomy: proximal/ mid 1/3
Subtotal gastrectomy: distal
Oesophagectomy: adenocarcinoma of oesophagogastric junction
Typical chemotherapy regimen for gastric cancer
Fluorouracil
Leucovorin
Oxaliplatin
Docetaxel
What therapy can be used for HER2 positive gastric cancer?
Trustazumab
