Gastric Acid & GI Hormones

Question 1

Give 4 main reasons for gastric acid secretion?

Answer 1

Denatures proteins Activates pepsinogen to pepsin Antibacterial Iron absorption

Question 2

Which cell is responsible for gastric acid secreted? In which part of the stomach are they predominantly found?

Answer 2

Parietal cells

Fudus/body of the stomach

Question 3

What are the three important mediators of gastric acid secretion?

Answer 3

Acetylcholine

Gastrin

Histamine

Question 4

Which hormones are responsible for stopping gastric acid secretion?

How do they elict these effects?

Answer 4

Somatostatin- inhibits gastrin and histamine secretion

Secretin- inhibits gastrin, stimulates somatostatin, stimulates HCO3-