Gas Transport In The Blood Part 2

Question 1

What are the means of CO2 transport in the blood

Answer 1

• Solution 10%
• As Bicarbonate 60%
• As Carbamino compounds 30%

Question 2

Explain CO2 in solution

Answer 2

About 10% of carried CO2 is in solution

CO2 is 20 times more soluble than oxygen

Question 3

Explain CO2 transport with bicarbonate

Answer 3

Most CO2 is transported in the blood as bicarbonate (60%)

Bicarbonate is formed in the blood by
CO2 + H2O = H2CO3 = H+ + HCO-3

Carbonic anhydride occurs in red blood cells

Question 4

Explain CO2 transport with carbamino compounds

Answer 4

Carbamino compounds are formed by combination of CO2 with the terminal amine groups in blood proteins
Especially globin of haemoglobin to give Carbamino-haemoglobin

Rapid even without enzyme
Reduced Hb can bind more CO2 than HbO2

Question 5

How does the Haldane effect and the Boher effect work in synchrony to facilitate liberation of O2 and uptake of CO2

Answer 5

The Boher and Haldane effete work in synchrony to facilitate O2 liberation and uptake of CO2 and CO2 generated H+ at tissues

Removing O2 from Hb increases the ability of Hb to pick up CO2 and CO2 generated H+ (Haldane effect)

O2-Hb dissociation curve is shifted to the right (facilitated by Boher effect)

Question 6

What happens with Hb at the lungs

Answer 6

At the lungs the Hb pick up the O2 which weakens it’s ability to bind CO2 and H+