Ganglionic Blockers HTN

Question 1

Mecamylamine

Answer 1

orphan drug for the treatment of Tourette’s

Question 2

Where do ganglionic blockers act

Answer 2

Paraysmpathetics/Sympathetics in cardiac and smooth muscle, gland calls, nerve terminals
Sympathetics in sweat glands, renal vasculare smooth muscle
Somatic skeletal muscle

Question 3

Effect of ganglionic blockers on arterioles

Answer 3

vasodilation; increased peripheral blood flow; hypotension

Question 4

Effect of ganglionic blockers on veins

Answer 4

Dilation; peripheral pooling of blood; decreased venous return; decreased cardiac output

Question 5

Effect of ganglionic blockers on heart

Answer 5

Tachycardia

Question 6

MOA of Trimethaphan

Answer 6

compete with ACh for nicotinic receptor sites; blocks initial ESPS and ganglionic transmission is inhibited

Question 7

Adverse effects of ganglionic blockers

Answer 7

Postural hypotension, tachycardia, arrhythmias, blurred vision, double vision, asthma secondary to histamine release, dry mouth, constipation, paralytic ileum, N/V, urinary retention, impotence, drowsiness, seizures, hallucinations, tremor, confusion, neuromuscular blockade