Gamétogenèse Flashcards

1
Q

CGP

A

= cell pluripotentes
identifiable sur dès la 2e semaine
expression gènes BMP4, Fragilis, Stella

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2
Q

Fragilis

A

confère aux cellules de l’épiblaste la compétence à devenir des CGP uniquement si ces cell expriment aussi Stella

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3
Q

Stella

A

premier marqueur de la diff germinale

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4
Q

migration CPG

A

pendant 3e semaine
4-6ème semaine

passive ou active
C-kit/ Steel

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5
Q

identification des CGP

A
facilement au stade 3eme semaine: 
grande taille
immunomarquage w/ AC spé:
Oct4 
Fragilis 
Stella 
VASA
BLIMP1
Phosphatase alcaline
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6
Q

gonades → sexe masculin

A

8-16 sem

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7
Q

gonades → sexe féminin

A

8-20 sem

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8
Q

phase menstruelle

A

J1-J5

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9
Q

phase proliférative

A

J5-J-14

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10
Q

phase lutéale

A

après ovulation (J14) libération de sécrétions glandulaires de J14-J27

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11
Q

ovogonies quittent le cycle et deviennent ovocytes I

A

à partir de la 12ème semaine

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12
Q

ovocyte I initie multiplication cellule

A

13ème semaine

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13
Q

chez foetus mitose et méiose coexistent

A

jusqu’au 5 ème mois = fin multiplication des ovogonies

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14
Q

CSF

A

cytostatic factor

facteur cytoplasmique ovocytaire qui bloque l’ovocyte II en méiose II

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15
Q

MPGF

A

male pronucleus growth factor

permet décondensation de la chromatine du sptz après la fécondation

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16
Q

GDF9

A

growth differenciation factor 9 de la superfamille des TGFbeta
permet à l’ovocyte d’induire mitoses des cellules folliculaires de la granulosa

17
Q

réserve ovocytaire 7ème mois vie intra-utérine

A

7 millions de follicules primordiaux (max)

18
Q

réserve ovocytaire naissance

A
  • 1 à 2 millions de follicules
19
Q

réserve ovocytaire puberté

A

400 000 follicules

~ 350-400 ovocytes seront ovulés au cours de la vie sexuelle