Gallbladder Flashcards
What is cholecystitis?
With or without stones
Acute infection of the gallbladder = filled with purulent fluid
S/Sx of cholecystitis
Causes pain, tenderness, rigid RUQ, N/V
- Very painful; the patient is usually in the fetal position and won’t let you touch their abdomen
1. Could be silent in old people
2. Fever
3. Low BG
4. High WBC
5. Pain radiating to shoulder
6. Pain that worsens after high fat meal
Types of cholecystitis
- Calculous (90%) = with stones
2. Acalculous = without stones
Calculous cholecystitis pathophysiology
- GB stone obstructs outflow of bile
- Bile remaining in GB initiates chemical reaction resulting in autolysis/edema
- Blood vessels are compressed in the GB
- Vascular supply is compromised
Potential Complications of calculous cholecystitis
- Gangrene/perforation of GB
- E. coli infection
- Bile peritonitis
Causes of acalculous cholecystitis
- Major surgery
- Trauma
- Burns
* An alteration in F/E in visceral circulation leads to bile stasis which increases bile viscosity (sludgy bile)
What is cholelithiasis?
- Formed in GB from solid constituents of bile
- Vary in size, shape, and composition
- Uncommon in children
- Increased risk after the age of 40
- Affects 1 in 3 over the age of 75 (but they usually have silent cholelithiasis)
Types of cholelithiasis stones
- Pigmented
2. Cholesterol
Pigmented Gallstones
- 25% of cases
- Formed from unconjugated pigment
- Increased in cirrhosis, hemodialysis, infected biliary tree
Cholesterol Gallstones
- 75% of cases
- 4 times higher in women over 40
- The 4 F’s (fat, fertile, fair, forty)
- Increased incidence in DM, GI disease, increased age
S/Sx of gallbladder disease
- Pain/biliary colic
- Jaundice
- Change in urine and stool color
- Vitamin deficiency
Why would someone with gallbladder disease experience jaundice?
Due to increased bile absorbed in the blood excreted through the skin (can be itchy)
What is Murphy’s sign?
Pain on palpation to RUQ
S/Sx of pain/biliary colic
- GB distended
- GB infected
- Murphy’s sign
- A/N/V
- Pain after high fat meal
- Unable to fully inspire (because they keep their diaphragm as high as they can; risk for respiratory issues like atelectasis)
Why can’t we give morphine sulfate for pain/biliary colic?
Because it spasms the Sphincter of Oddi which will aggravate the GB
Why would a patient experience vitamin deficiencies with gallbladder disease?
Because obstruction of bile flow interferes with ADEK absorption = monitor PT for low vitamin K
Diagnostic Tests for Gallbladder
- Abdominal X-ray
- Ultrasonography or ultrasound
- Cholecystography or gallbladder series
- Radionuclide Imaging or Cholescintography
- Endoscopic Retrograde Cholangiopancreatography (ERCP)
- Percutaneous Transhepatic Cholangiography
Abdominal X-rays
Note gallstones but only 15-20% are calcified
Gold Standard of diagnostic gallbladder tests
Ultrasonograpy or ultrasound