Gall Bladder and Pancreas Histo

Question 1

Gall Bladder Histo

Answer 1

• Highly folded simple columnar epithelium, lamina propria and submucosa
• Irregular patches of smooth muscle scattered in lamina propria but no organized muscle layers
• Epithelium is so highly folded that it often creates artifacts that look like closed off sinuses (Rokitansky-Aschoff sinuses)

Question 2

What is gall bladder epithelium line with?

Answer 2

• Lined w/ only 1 cell type (absorptive cells) w/ claudins b/n them
• Absorb fluid from bile ducts by first pumping Na+ into lateral spaces between cells which then draws water into these spaces

Question 3

Pancreas Exocrine Histo

Answer 3

• acini (basophilic w/ granules) w/ 3 levels of ducts

1- Intercalated - smaller diameter than acinus (secrete bicarb)
2- Intralobular - same diameter as acinus
3- Interlobular - large and in connective tissue septa

Question 4

Pancreas Endocrine Histo

Answer 4

• islets of Langerhans
• Pale w/ clusters of 3 cell types
  - Alpha- secrete glucagon
  - Beta - secrete insulin
  - Delta - secrete somatostatin