gall bladder

Question 1

hepatic arch zone 1

Answer 1

portal aea; 1st to suffer toxins or viral hepatitis

Question 2

hep zone 2

Answer 2

in between

Question 3

hep zone 3

Answer 3

CV area–1st to suffer ischemia, etoh hep

Question 4

space of disse

Answer 4

perisinusoidal space between fenestrated endo & cords

basal surface of hepatocytes comms w/ sinusoid via space of disse

gap jx sep but allow passage of ions and water

Question 5

hepatocyte secretion into bile canniculus is an

Answer 5

active process (bile salt pump)— needs microvllli and cytoskeleton

Question 6

cholangiocytes add

Answer 6

H20 ad HCO3-

Question 7

what concentrates hepatic bile

Answer 7

na pumps

Question 8

3 components of gallstone formation

Answer 8

increase cholesterol
decease bile acids
decrease phospholipids

Question 9

2 fux of bile

Answer 9

fat digestion and absorption

elimination of waste: cholesterol

Question 10

where are bile acids reabsorbed

Answer 10

terminal ileum

Question 11

gilbert syndrome

Answer 11

problems w/ uptake–>increase unconj

Question 12

crigler-najjar

Answer 12

problem w/ conj–>incr conj

Question 13

dubin johnson/rotor

Answer 13

probs w/ excretion–inc conj

Question 14

pregnancy can cause

Answer 14

benign intrahepatic ostruction secondary to increased estrogen

Question 15

what do cholseterol stonse look like

Answer 15

yellowish and radiolucent

Question 16

pigment stones are

Answer 16

radiopaque

Question 17

the smaller the stone

Answer 17

more likely it is to cause problems

Question 18

labs in cholecystitis

Answer 18

increase billi, AST, ALT, WBC w/ left shift

Question 19

Rokitasky-Aschoff sinus

Answer 19

entrapped crypts form pseudodiverticula or pockets in GB wall

Question 20

porcelian gallbladder

Answer 20

extensive calcifications–variant of chronic chole

increase risk of gb carcinoma

Question 21

strawberry gallbladder

Answer 21

choleseral esters accum in lamina propia–>speckled yellow surface
foamy lipid laden mos

Question 22

labs in choledocholithiasis

Answer 22

increase billi, ALP, AST, ALT

Question 23

risk factors of gb carcinoma

Answer 23

galllstonse, chronic ccitis, chronic infx, primary sclerosing cholangitis

Question 24

klatskin’s tumor

Answer 24

cholangicarcinoma

malig of bile ducts

Question 25

sclerosing cholangitis

Answer 25

chronic fibrosing inflam process of the bile ducts that obliterate the bile duct

Question 26

type choledochal cysts

Answer 26

mos commo

dffuse enlargment of cystic duct

Question 27

type V choledochal cysts

Answer 27

intrahepatic cysts (caroli’s disease)–associated w/ PKD

Question 28

gold sandard dx gal stone dz

Answer 28

endoscopic ultrasound

Question 29

gold standard choledocholithiasis

Answer 29

ERCP