G6PD Deficiency Flashcards
1
Q
G6PD is the commonest…..
A
Red blood cell enzyme defect.
2
Q
How is it inherited?
A
X-linkned recessive
3
Q
Who is it most common in?
A
Mediterranean and African
4
Q
What food can precipitate a crisi?
A
Fava beans
5
Q
What are some features of G6PD?
A
- Neonatal jaundice is often seen
- Intravascular haemolysis
- Gallstones are common
- Splenomegaly may be present
- Heinz bodies on blood films (also sulfasalazine causes heinz body anaemia)
6
Q
How is it diagnosed?
A
G6PD enzyme assay
7
Q
What are some drugs that are thought to cause hemolysis in G6PD?
A
- Ciprofloxacin
- Sulph drugs - sulfonylureas, sulphasalzine, Sulfonylureas.
- Anti-malarials - Primaquin
8
Q
What are some drugs that are thought to be safe in G6PD?
A
- Penicillins
- Cephalosporins
- Macrolides
- Tetracyclines
- Trimethoprim
9
Q
Describe the differences and similarities of G6PD and Hereditary Spherocytosis?
A
