Future Treatments for Mood Disorders

Question 1

Dextromethorphan

Answer 1

1. is a weak NMDA receptor antagonist
2. strong binding for SERT
3. strong binding for sigma 1 receptors
4. rapidly metabolized by CYP450 2D6.

Question 2

Dexromethorphan-bupropion and Dextromethorphan-quinidine

Answer 2

These combinations can help to inhibit the CYP450 2D6

Question 3

Dextromethadone (Stahl p. 355).

Answer 3

1. used for medication -assisted treatment of opiod use disorder
2. Is a u-opoid agonist

Question 4

Psilocybin

Answer 4

1. 5HT2a agonist
2. additional action at serotonin receptors
3. known as magic mushrooms.