future HIV therapies

Question 1

controls replication of the human immunodeficiency virus type-1 (HIV) by affecting different stages of the viral life cycle through attacking viral enzymes- including cell entry, reverse transcription, integration, and assembling of the viron

Answer 1

Combined Antiretroviral Therapy (cART)

Question 2

Retroviral drugs attack ____ and ____

Answer 2

replication and plasma viremia

Question 3

resting, memory CD4+ T cells carrying proviral DNA

Answer 3

Latent-HIV infected cells

Question 4

which cell remains a major obstacle for HIV eradication

Answer 4

Latent-HIV infected cells

Question 5

once Latent-HIV infected cells are re-activated, these cells are potential source of

Answer 5

viruses

Question 6

_____ are not replicating nor recognized by immune system (escape immune attack)

Answer 6

Latent-HIV infected cells

Question 7

latent reservoirs are ____ and ____ to different treatment regimen

Answer 7

stable; resistant

Question 8

how does latent cells recognized by immune system?

Answer 8

need presentation of viral peptides by MHC class I

Question 9

___ includes treatments of stem cell transplantation, gene therapy

Answer 9

sterilizing cure