Furosemide

Question 1

class

Answer 1

loop diuretic

Question 2

mechanism of action

Answer 2

Pharmacologic: Inhibits electrolyte reabsorption in the ascending Loop of Henle.
Promotes excretion of sodium, potassium, chloride. Vasodilation increases venous
capacitance and decreases afterload.
Clinical: Diuresis

Question 3

indications for field use

Answer 3

Pulmonary edema; congestive heart failure

Question 4

contraindications

Answer 4

 Anuria (relative)
 Hypovolemia
 Hypotension

Question 5

adverse reactions

Answer 5

 May exacerbate hypovolemia
 Hyperglycemia (due to hemoconcentration)
 Hypokalemia
 May decrease the response to pressors

Question 6

incompatibilities/drug interactions

Answer 6

Increased effects with other antihypertensives

Question 7

adult dose

Answer 7

On oral furosemide therapy: Consider initial dose of 2 times daily oral dose, if no
effect in 20 minutes may double initial dose.
Not on oral furosemide therapy: 0.5-1 mg/kg to a maximum of 2 mg/kg (usually 20-40
mg) IV slowly.

Question 8

ped dose

Answer 8

1 mg/kg IV slowly

Question 9

routes of administration

Answer 9

slow IV push

Question 10

onset of action

Answer 10

5 minutes (vasodilation)

Question 11

peak effects

Answer 11

20-60 minutes (diuresis)

Question 12

duration of action

Answer 12

variable

Question 13

AZ drug box minimum

Answer 13

optional 100 mg

Question 14

special notes

Answer 14

 Ototoxicity and resulting deafness can occur.
 Since furosemide is a sulfonamide derivative, it may induce allergic reactions in patients
with sensitivity to sulfonamides (sulfa drugs).