Fungi

Question 1

Yeasts

Answer 1

Single cell Forms chains reproduces by budding

Question 2

Molds

Answer 2

Eukaryotic Multicellular Form tubular structures with or without cross walls Many human pathogens have no known sexual phase

Question 3

Mycotic Hypersensitivity

Answer 3

Allergy to fungus

Question 4

Mycotoxicosis

Answer 4

Toxic fungus substances in rye, wheat, etc. St. Anthony’s Fire associated with mycotoxicosis

Question 5

Mycetismus

Answer 5

Mushroom poisoning (doing shrooms)

Question 6

Are fungal infections common? Why or why not?

Answer 6

No. For several reasons, Fungi are wimpy and the human immune system is strong. Fungi are also hard to come by.

Question 7

Types of fungal infections

Answer 7

Systemic: Dimorphic (switch between yeast and mold) and Opportunistic (Most systemic infections are by inhalation) Superficial: Cutaneous and Subcutaneous (from cuts and scratches) (superficial mycosis are the most contageous

Question 8

Amphotericin B, Nystatin, Natamycin, Pimaricin (What do they target)

Answer 8

Target sterols in fungal membrane. The have polar and non-polar sites and form a barrel through the membrane)

Question 9

Imidazoles, Triazoles (What do they target?)

Answer 9

Inhibit the formation of ergosterol from squalene. (imidazoles have hormonal side effects)

Question 10

Flucytosine

Answer 10

Makes false nucleotides to inhibit fungal synthesis

Question 11

Echinocandins

Answer 11

Non-competative inhibitors of Beta-glucan sythase. Prevents fungal cell wall synthesis

Question 12

Griseofulvin

Answer 12

Binds to tubulin to prevent mitosis in fungus