Fungal infections

Question 1

Examples of triazole antigungals?

Answer 1

fluconazole

itraconazole

Question 2

Examples of imidazole antifungals?

Answer 2

clotrimazole
ketoconazole
miconazole

Question 3

Examples of polyene antigungals?

Answer 3

amphotericin

nystatin

Question 4

Itraconazole side effects?

Answer 4

heart failure

heaptotoxicity

Question 5

Antacids are to be avoided with which antifungals?

Answer 5

itraconazole

ketoconazole

Question 6

Why is ORAL ketoconazole only used for cushing’s?

Answer 6

due to fatal hepatotoxicity risk, not worth it for a fungal infection (topical ketoconazole still used though)
also prolongs QT

Question 7

Why do you need to monitor IV use of amphotericin B for 30mins?

Answer 7

as can cause arrhythmias

Question 8

Which antifungal do you need to wear SPF with?

Answer 8

voriconazole - LFTs to be checked before, weekly for a month then monthly

Question 9

Fluconazole and pregnancy?

Answer 9

AVOID

Question 10

Remember fluconazole is?

Answer 10

a CYP INHIBITOR!

Question 11

miconazole interaction?

Answer 11

warfarin

Question 12

vaginal thrush tx?

Answer 12

oral fluclox or topical imadazole e.g. clotrimazole

Question 13

tinea capatis, corporis, cruris and pedis tx?

Answer 13

miconazole
clotrimazole
terbinafine (for athletes foot)

Question 14

tinea ungium tx? (fungal nail infection)

Answer 14

amorolfine (6 months for nails and 9-12 months for toe nails)
max 2 nails if treating OTC