Fungal Infections

Question 1

Treatment of Histoplasmosis

Answer 1

Chronic or Disseminated - Amphotericin B

Mild or maintenance - Ketoconazole or Itraconazole

Question 2

Treatment for Cryptococcosis

Answer 2

Severe - Amphotericin

Less severe - Fluconazole

Question 3

Treatment for Coccidiomycosis

Answer 3

Disseminated - Amphotericin

Milder - Fluconazole or Itraconazole

Question 4

Treatment for Zygomycosis

Answer 4

IV amphotericin B

Control Diabetes if diabetic

Question 5

Treatment for Aspergillosis

Answer 5

Non invasive- Debridement

Invasive- Voriconazole or Itraconazole

Question 6

Voriconazole

Answer 6

Triazole, IV or oral
Can treat Candida, Aspergillus, 
SE - photosensitivity
Expensive
First line against invasive aspergillosis

Question 7

Itraconazole

Answer 7

Well-absorbed, daily dosing, minimal SE

Expensive

Question 8

Ketoconazole

Answer 8

Single convenient daily dose
Drug interaction problems
Idiosyncratic hepatotoxicity

Question 9

Diagnosis of Candidiasis

Answer 9

Clinical signs/symptoms often sufficient
Exfoliative Cytology
Culture- not helpful
Biopsy- not necessary

Question 10

Nystatin/Mycostatin

Answer 10

Not absorbed systemically, must be in contact with organism to be effective
Bitter taste, multiple dosing

Question 11

Clotrimazole/Mycelex

Answer 11

Not absorbed systemically, no SE
Pleasant tasting lozenges
Multiple dosing (5 x day)

Question 12

Fluconazole

Answer 12

Triazole
Absorbed systemically, No SE
Convenient daily dosing
Expensive

Question 13

Topical Antifungal Creams

Answer 13

Mycolog II and Vytone

Question 14

Mycolog II

Answer 14

Nystatin + Triamcinolone

Question 15

Vytone

Answer 15

Iodoquinol + Hydrocortisone