Fundamentals of science

Question 1

What is inflammation?

Answer 1

The physiological reaction to foreign bodies aka pathogens.

Question 2

What are the clinical features of inflammation?

Answer 2

Rubor, Calor ,Tumor ,Dolor, loss of function

Question 3

What kind of things trigger inflammation?

Answer 3

Foreign bodies ,direct damage or damage associated molecules

Question 4

What kind of cells are responsible for detecting foreign bodies?

Answer 4

Sentinel cells

Question 5

What kind of cells are responsible for the signalling of wbc in inflammation?

Answer 5

Cytokines such as interleukins

Question 6

What are the 4 different cascades involved in inflammation?

Answer 6

Coagulation cascade, Fibrinolytic cascade, Complement cascade and Kinin cascade.

Question 7

What is the complements cascades main role in inflammation?

Answer 7

Opsonises to promote phagocytes.

Question 8

What is E-selectins role in inflammation?

Answer 8

It acts as an adhesive allowing wbc to stick to the site of injury.

Question 9

What is the 1st line treatment for inflammation?

Answer 9

Rest, Ice, Compression, Elevation

Question 10

What is the 2nd line of treatment for inflammation?

Answer 10

NSAIDS as they inhibit prostaglandins that promote inflammation

Question 11

What is the 3rd line of treatment of inflammation?

Answer 11

Steroids

note= last resort as they have a lot of side effects.