Functional bowel disorders Flashcards

1
Q

Define functional bowel disorders

A
  • No detectable pathology
    • Related to gut function
    • “software faults”
    • Good long term prognosis
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2
Q

Give some examples of functional bowel disorders

A
  • Oesophageal spasm
    • Non-ulcer dyspepsia (NUD)
    • Biliary dyskinesia
    • Irritable bowel syndrome
    • Slow transit constipation
    • Drug related effects
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3
Q

Understand the impact of functional bowel disorders and the role of psychological factors

A
  • Very common cause of initial and return medical consultations
    • Large impact on quality of life
    • Large cause of work absences
    • Psychological factors are important
    • Not associated with the development of a serious pathology
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4
Q

What is non-ulcer dyspepsia?

A
  • Dyspeptic type pain

- No ulcer on endoscopy (H. pylori status varies

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5
Q

What is non-ulcer dyspepsia caused by?

A

probably not a single disease

  • Reflux
  • Low grade duodenal ulceration
  • Delayed gastric emptying
  • Irritable bowel syndrome
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6
Q

How do you diagnose non-ulcer dyspepsia?

A
  • Careful History and Examination
    - Family History
  • Gastric Cancer rare in those under 45 years
  • H. pylori status
  • Alarm symptoms
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7
Q

How do you treat non-ulcer dyspepsia?

A
  • If all negative: Treat symptomatically
  • If H. pylori positive: Eradication therapy
  • If Doubt: Endoscopy
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8
Q

What is nausea?

A

The sensation of feeling sick

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9
Q

What is retching?

A
  • Dry heaves

- Antrum contracts, glottis closed

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10
Q

What is vomiting?

A

Contents expelled

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11
Q

What are the sympathetic and Vagal components of vomiting and nausea?

A
  • Vomiting Centre (may not exist as entity)
  • Chemoreceptor Trigger Zone (CTZ)
    - Receptors for opiates
    - Digoxin
    - Chemotherapy
    - Uraemia
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12
Q

What would the history of nausea and vomiting be?

A
Length of time after food
- Immediate
       - Psychogenic
- 1 hour or more
       - Pyloric obstruction
       - Motility disorders
                ~ Diabetes 
                ~ Post gastrectomy
- 12 hours 
       - Obstruction etc
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13
Q

What are the functional causes of nausea and vomiting

A
  • Drugs
  • Pregnancy
  • Migraine
  • Cyclical Vomiting Syndrome
    - Onset often in childhood
    - Recurrent episodes 2-3 x year – 2-3 x month
  • Alcohol
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14
Q

What is psychogenic vomiting?

A
  • Often young women
  • Often for years
  • May have no preceding nausea
  • May be self induced (overlap with bulimia)
  • Appetite usually not disturbed but may lose weight
  • Often stops shortly after admission
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15
Q

What are alarm symptoms?

A
  • Age > 50
  • Short symptom history
  • Unintentional weight loss
  • Nocturnal symptoms
  • Male sex
  • Family history of bowel/ ovarian cancer
  • Anaemia
  • Rectal bleeding
  • Recent antibiotic use
  • Abdominal mass
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16
Q

What is the aetiology of constipation?

A
  • Systemic: Diabetes mellitus, hypothyroidism, hypercalcaemia
  • Neurogenic: Autonomic neuropathies, Parkinson’s disease, strokes, multiple sclerosis, spina bifida
  • Organic: Strictures, tumours, diverticular disease, proctitis, anal fissure
  • Functional: Megacolon, idiopathic constipation, depression, psychosis, institutionalised patients
17
Q

What are the clinical features of irritable bowel syndrome (IBS)

A
  • Abdominal pain
  • Altered bowel habit
  • Abdominal bloating
  • Belching wind and flatus
  • Mucous
    Symptoms of IBS usually occur in chronic relapsing, remitting manner
18
Q

Describe the abdominal pain of IBS

A
  • Very variable
    - Vague
    - Bloating
    - Burning
    - Sharp
  • Occasionally radiates, often to lower back
  • Pain can be replicated by balloon inflation suggesting it may be due to bowel distension
  • Often altered by bowel action
  • Rarely occurs at night
19
Q

What are the investigations for IBS?

A
  • Blood analysis
    - FBC
    - U & E, LFTs, Ca
    - CRP
    - TFTs
    - Coeliac serology
  • Stool Culture
  • Calprotectin
    - Rectal Examination and FOB
    - ?Colonoscopy
20
Q

What is calprotectin?

A
  • Calprotectin released by inflamed gut mucosa

- Used for differentiating IBS from IBD and for monitoring IBD

21
Q

What is the treatment of IBS?

A
  • A firm diagnosis
  • Education and reassurance
  • Dietetic review
    - Tea, coffee, alcohol, sweetener
    - Lactose, gluten exclusion trial
    - FODMAP
22
Q

What is FODMAP?

A
  • Fermentable Oligo-, Di- and Mono-Saccharides and Polyols
    - Fructose
    - Lactose
    - fructins
    - galactans
    - Polyols
23
Q

What drugs can you take to help with the pain of IBS?

A
  • Antispasmodics
  • Linaclotide (IBS-C)
  • Antidepressants
    - TCAs (IBS-D)
    - SSRIs (IBS-C)
24
Q

What drugs can you take to help with the bloating of IBS? (what should you avoid?)

A
  • Some probiotics
  • Linaclotide (IBS-C)
  • Avoid: Bulking agents/ fibre
25
Q

What drugs can you take to help with constipation in IBS? (what should you avoid?)

A
  • Laxatives
    - Bulking agents/ fibre (episodic)
    - softeners (adjuvant)
    - Stimulants (occasional)
    - Osmotics (regular)
  • Linaclotide
  • Avoid: TCAs, FODMAP
26
Q

What drugs can you take to help with diarrhoea? (what should you avoid?)

A
  • Anti motility agents
  • FODMAP
  • Avoid: SSRIs
27
Q

What are the psychological interventions for IBS? What are they particularly effective for?

A
  • Relaxation training: Diarrhoea, psychological co-morbidity
  • Hypnotherapy: pain, constipation, flatulence, anxiety
  • CBT: Abdominal pain, bloating, flatulence
  • Psycho dynamic interpersonal therapy: a history of abuse
28
Q

What causes IBS?

A
  • Altered Motility
  • Visceral Hypersensitivity
  • Stress, Anxiety, Depression
29
Q

What is the difference between IBS-C and D?

A
  • In IBS-D, muscular contractions may be stronger and more frequent than normal. In IBS-C, contractions may be reduced
  • In IBS-D, the response to these normal triggers may be stronger than normal. In IBS-C, the response may be reduced