Functional and Structural Connectivity Flashcards
Functional Connectivity definition?
virtual connections between brain regions, connected through activities being temporally correlated.
Name one method used to look at functional connectivity between brain regions. How does it work
Seeding. Shows if activities in other brain regions have significant relationship with seed regions, either at rest or during a task.
Give an example of how a method is used for looking at functional connectivity, including brain region names.
seeding an area in prefrontal cortex as they are involved in modulating activities in posterior brain regions.
Depue et al., 2017 showed what, in relation to seeding?
more mutual relationship between activity in right dorsolateral prefrontal cortex and hippocampus have better ability to retrieve memories.
Spielberg et al., 2015
Graph Theory
What is Graph Theory?
suggests brain is composed of 200 nodes that interact but are not physically connected. under attentionally demanding conditions, organisation of nodes is flexible and reconfigures to allow efficient information flow.
Structural Connectivity definition?
anatomical links between brain regions, physically connected through white matter tracts made of myelinated axons.
What is an example of structural connectivity?
corpus callosum physically connects left and right hemispheres of brain, connects homologous regions in each hemisphere
Hofer and Frahm., 2006
corpus callossum connection of homologous regions of brain
Give examples of structural connectivity, including brain region names.
fiber tracts connect frontal regions to more posterior regions, such as occipitofrontal fasciculus which connects occipital lobe and frontal lobe
controls structures processing sensory information.
what connects the frontal lobe to the anterior temporal lobe? what is this involved in?
uncinate fasciculus, involved in language and emotional processing
DTI
Diffusion Tensor Imaging
what is DTI used for?
Imaging white matter tracts
What can DTI show?
the integrity and anatomical connectivity between brain regions.
What can DTI show about water diffusion?
the main direction of it, which shows the structural integrity of white matter tracts.
Who did research on water diffusion in DTI?
Mori & Zhang., 2006
Sigal et al., 2012
looking at less diffusion in brain regions, as a result of demyelination in disorders- sclerosis.
What does MRI show in regards to connectivity?
links structural and functional connectivity, shows white and grey matter and brain functions.
How do MRI work?
constant magnetic field, alterations in magnetic field are induced and response atoms in brain used to present maps of brains structure and function.
DMN
Default Mode Network