Functional and Structural Connectivity Flashcards

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1
Q

Functional Connectivity definition?

A

virtual connections between brain regions, connected through activities being temporally correlated.

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2
Q

Name one method used to look at functional connectivity between brain regions. How does it work

A

Seeding. Shows if activities in other brain regions have significant relationship with seed regions, either at rest or during a task.

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3
Q

Give an example of how a method is used for looking at functional connectivity, including brain region names.

A

seeding an area in prefrontal cortex as they are involved in modulating activities in posterior brain regions.

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4
Q

Depue et al., 2017 showed what, in relation to seeding?

A

more mutual relationship between activity in right dorsolateral prefrontal cortex and hippocampus have better ability to retrieve memories.

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5
Q

Spielberg et al., 2015

A

Graph Theory

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6
Q

What is Graph Theory?

A

suggests brain is composed of 200 nodes that interact but are not physically connected. under attentionally demanding conditions, organisation of nodes is flexible and reconfigures to allow efficient information flow.

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7
Q

Structural Connectivity definition?

A

anatomical links between brain regions, physically connected through white matter tracts made of myelinated axons.

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8
Q

What is an example of structural connectivity?

A

corpus callosum physically connects left and right hemispheres of brain, connects homologous regions in each hemisphere

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9
Q

Hofer and Frahm., 2006

A

corpus callossum connection of homologous regions of brain

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10
Q

Give examples of structural connectivity, including brain region names.

A

fiber tracts connect frontal regions to more posterior regions, such as occipitofrontal fasciculus which connects occipital lobe and frontal lobe

controls structures processing sensory information.

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11
Q

what connects the frontal lobe to the anterior temporal lobe? what is this involved in?

A

uncinate fasciculus, involved in language and emotional processing

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12
Q

DTI

A

Diffusion Tensor Imaging

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13
Q

what is DTI used for?

A

Imaging white matter tracts

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14
Q

What can DTI show?

A

the integrity and anatomical connectivity between brain regions.

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15
Q

What can DTI show about water diffusion?

A

the main direction of it, which shows the structural integrity of white matter tracts.

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16
Q

Who did research on water diffusion in DTI?

A

Mori & Zhang., 2006

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17
Q

Sigal et al., 2012

A

looking at less diffusion in brain regions, as a result of demyelination in disorders- sclerosis.

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18
Q

What does MRI show in regards to connectivity?

A

links structural and functional connectivity, shows white and grey matter and brain functions.

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19
Q

How do MRI work?

A

constant magnetic field, alterations in magnetic field are induced and response atoms in brain used to present maps of brains structure and function.

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20
Q

DMN

A

Default Mode Network

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21
Q

When is the DMN engaged?

A

When the brain is not engaged in specific attention- demanding task

22
Q

What is the thought that is engaged in DMN?

A

Stimulus-independent thoughts detached from external environment.

23
Q

What is in focus when DMN is engaged?

A

introspection, self-reflection and thoughts of the future.

24
Q

Buckner et al., 2008

A

showed introspection, self-reflection and thoughts of future are active in DMN.

25
Q

Fox et al., 2005

A

DMN operates as neural activity spontaneously rises and falls together in temporal synchrony

26
Q

What do cogntitions tend to gravitate to when not attending to specific stimuli?

A

thoughts and feelings

27
Q

What did Flavell et al., 2000 show?

A

100% of adults reported ongoing thought when asked to think of nothing

28
Q

What did Berger 1929 show in regards to brain activity and DMN?

A

brain is also active at rest, shown using EEG

29
Q

what has fMRI shown in regards to brain activity and DMN?

A

specific regions active when at rest, these regions constitute DMN

30
Q

What is DMN associated with, in accordance to cognitions?

A

free and voluntary thought, and can help understand how free thought is altered in psychiatric conditions- Sz

31
Q

Four core regions of DMN?

A

Medial Prefrontal Cortex (MPFC)
Posterior Cingulate Cortex (PCC)
Left and right Inferior Parietal Lobules (IPLs).

32
Q

MPFC?

A

Medial Prefrontal Cortex

33
Q

PCC

A

Posterior Cingulate Cortex

34
Q

IPLs

A

left and right Inferior Parietal Lobules

35
Q

task negative network

A

regions of DMN are functionally connected as they dampen activation altogether.

36
Q

What is suppression of DMN associated with?

A

better performance on attention-demanding tasks

37
Q

SN

A

Salience Network

38
Q

CEN

A

Central Executive Network

39
Q

What can CEN and SN show?

A

structural and functional abnormalities in brain in Sz.

40
Q

what is the function of the SN?

A

switching between CN and DMN

41
Q

What does the CEN control?

A

high-level cognitive functions.

42
Q

Uddin et al., 2011 showed…

A

interactions between SN, CEN and DMN

43
Q

What did Uddin et al., 2011 find?

A

functional coupling between nodes that are stronger in adults than in children in rFIC

44
Q

rFIC

A

right Fronto-Insular Cortex

45
Q

What does the development of rFIC suggest?

A

changes in functional connectivity is directly linked to development of structural connectivity.

46
Q

DTI looked at rFIC and supported the development of rFIC, how?

A

showed increased structural integrity in adults in within- and between- network pathways linked to rFIC.

47
Q

Why is structural maturation of the rFIC important to humans?

A

it supports complex, flexible cognitive processes in adulthood.

48
Q

How is CEN and SN structurally connected?

A

fractional anisotropy

49
Q

What is shown when looking at fractional anisotropy in DTI?

A

fiber density, axonal diameter and white matter

50
Q

What does fractional anisotropy show about connectivity?

A

functional connectivity of networks are also structurally connected.

51
Q

What does the SN do?

A

filters stimuli, recruits functional networks and allows for complex functions to occur.

52
Q

Examples of SN complex functions

A

communication and social behaviour