Functional

Question 1

What is the benefit of DBS for Parkinson’s disease in regard to ON and OFF time?

Answer 1

DBS may allow more 4 hr more ON time in PD without dyskinesias

Question 2

What is the first line treatment for craniocervical dystonia?

Answer 2

Botox injection

Question 3

What are signs and symptoms of baclofen withdrawal?

Answer 3

Hyperthermia, Hyperreflexia, Increased spasticity, Seizures, Delirium

Question 4

Where is the internal capsule in relation to the STN?

Answer 4

Lateral and anterior to STN

Question 5

What is the FDA approved DBS target for OCD?

Answer 5

Ventral striatum/Ventral capsule

Question 6

What are the two targets used in DBS treatment of PD? Which target has a greater effect on medication reduction?

Answer 6

STN and GPi

STN has greater effect on medication reduction

Question 7

What is the DBS structure for nociceptive pain?

Answer 7

Periaqueductal Gray

Question 8

What is the most useful physical sign to monitor when programming the DBS in patients with PD and why?

Answer 8

Rigidity. Because it is fairly constant and changes quickly depending on the setting changes (tremors are not great for this purpose because they fluctuate throughout the day)

Question 9

What is the best predictor of DBS success for PD?

Answer 9

Responsiveness to levodopa

Question 10

In studies examining GPi DBS for generalized dystonia, improvements in symptoms was seen at what time interval post-implantation?

Answer 10

3 months