Function Of The Kidneys Flashcards
Filter Excrete Maintain blood volume
Functions of the kidneys
Filter:filters blood (liquid part , Plasma)
Excretion: getting rid of things that kidney filters
Maintain blood volume: maintain normal Plasma volume for B/P
Renal capsule
Surrounds kidneys directly
Some form of connective tissue, adipose tissue
adipose capsule
Superficial
- Layer of fat that surrounds the kidneys
- protects kidneys
- helps hold kidneys in place
Medulla ( pyramid)
Intersection ( inner region )
How many lobes per kidney
7 , 10-12 lobes per kidney
Referred to as renal column
Structure that makes urine
Kidneys
Drains the kidneys
Ureters
Storage unit for urine
Bladder
Structure of the how we empty the bladder w/urine leaving body
Urethra
Cystitis
Infection in bladder
Pyelitis
Infection ureter
Peeing is classified as which system
Peeing is pns
Urine formation is classified as what system
Urine formation is sns
Nephron
Working/ important part of the kidney
Million nephrons per kidney
Make up a lot of functions in kidneys
Two types of nephrons
- Cortical: 80-85% this type
2. Juxtaglomerular: remaining is 15-20%
Renal ptosis
Kidneys decrease in space/ decreased in position , drooping “dropped down”
Renal ptosis can cause
A kinked ureter
Hydronephrosis
Water on kidneys
** if kidneys can’t drain urine , will begin to compress the structures inside kidneys & you will do damage to the kidneys
Glomerular capsule has to regions to it
- Partial layer : simple squamous
- podocytes: visceral
** will help form a membrane
Renal sinus
Contain blood vessels, renal sinus , includes other structure
Plasma will do 1 of 2 things
- take things from there and put it back in the blood
2. Or it’s going to leave it in there ( if it’s left in the tube , it will be removed as urine )
Point of renal system
Introduce blood into kidneys
Which renal artery is longer
Right renal artery will be longer because of the proximity to the aorta
Which renal vein is shorter
Right renal vein is shorter because it is closer to the aorta
Which renal vein is longer
Left renal vein will be longer bwcauee its further away from the aorta
How many liters of blood go into the kidneys
- 5 liters go into the kidneys
Calyces (2 types)
- minor
- major
* * drains to pelvis almost like a blood flow
Glomerular capsule (bowman’s)
“baseball mit”
surrounds glomerulus
renal tubular system
- brings blood into kidneys
- introducing blood/ plasma part of blood to renal tubular system
- will change its environment, so that we can make the appropriate concentration volume of urine
Glomerulus ( blood flow in & out of)
capillary
interweaving capillary system
Renal pyramid
striated due to the conducting ducts
Juxtamedullary glomerular complex ( apparatus )
(JGA / JGC )
plays a role in in regulating B/P & amount of fluid that leaves
mascula densa
referred to as osmo receptors
- role is to tell how many components ( how many things are dissolved in fluid
Extraglomular mesangial cells
“extra”
Granular cells ( juxtaglomerular cells)
line the wall
-specialized smooth muscle cell
renin
- comes from granular cells
-
Afferent arterial
brings things in
- blood or vessels that bring blood into glomerulus
efferent arterial
takes things out
filtration slits
spaces that allows things to pass through it ( not everything is absorbed )
Collecting ducts
-will drain more than one nephron
Cortical nephron
surrounded by peritubular
juxtamedullary
has a peritubular , but it is not referred as peritubular, but instead vasa recta
-Vasa recta surrounds it
Juxtaglomerular is made up of (3)
- mascula densa
- extraglomerular (mesangial cells)
- granular cells
* **play a big role in regulating B/P & fluid that leaves
Filtration membrane
share a basement membrane
Glomerular mesangial cells have two functions
- ability to contract
- can decrease the the size of glomerulus ( if you decrease the size, not much blood is filtered) or not much blood comes in. if it cant filter enough blood, not much fluid will be leaving blood or going into tubular system - acts as a macrophage (cells are able to undergo phagocytosis when pathogens are in the area
peritubular
surrounds tubular system
3 factors that will influence glomerular filtration
- net filtration pressure ( most)
- total surface area ( less important)
- filtration membrane permeability
Net filtration pressure
how things move out of capillary
4 net filtration pressures
- hydrostatic pressure is fluid pressure, a pushing pressure
- hydrostatic pressure
- onconic pressure
- no forth pressure
Tubular reabsorption
is where fluids , particles & tubular system move back into the blood , to the peritubular capillary
Tubular secretion
fluid & particles moving from the peritubular capillaries back into the tubular system
osmolality
solutes / 1 liter fluids (solvent)
stuff in fluid
Renin
causes B/P to increase
renin is released when:
- decrease in stretch in JG cells
- detect decrease in sodium chloride in mascula densa
- beta 1 receptors
Renin activates
Angiotensinogen
angiotensinogen activates
angiotensin 1 , which causes the formation of angiotensin 2
Angiotensin will encounter
ACE
Angiotensin 2
- very potent
- increases sodium reabsorption
- increases ADH
- increases thirst
blood pressure equals
C.O. X resistance
Cardiac output equals
Heart rate x Stroke Volume
Blood Pressure equals
Heart rate x stroke volume x resistance
Map equals
systolic + diastolic + diastolic/ 3
Nervous system when activated causes ?
vasoconstriction
Collecting duct cells
- principal cells - utilize movement of sodium
2. intercalated cells - type A help w/ acid, typle B help w/ base
Apical microvilli
increase absorption
Distal convoluted Tubule cells
- Ascending - simple cuboidal (does not have microvilli)
- descending - simple squamous
( fluid inside is further away than proximal convoluted tubule )
Glomerular filtration
ability of leaving , as long as its not cells or proteins “ stuff moving from here to there”
passive
does not take any energy , just move move down
nonselective
low b/p =
does not profuse kidneys
liver damage =
decease in amount of proteins in the blood
pressure would be lower
tissue or membrane damage , w/ disease process =
more things would go out
NFP(Net Filtration Pressure)
has hydrostatic pressure pushing out, on-conic pressure pulling in, hydrostatic pressure in glomerular capsule pulling in
nephron loop
- descending limb
2. ascending limb
together glomerular capsule & glomerulus are referred as
renal corpuscle
3 things that regulate renin release
- Decrease in stretch of jg cells triggers renin release.
- macula densa cells that detect a decrease in osmolarity ( decrease in sodium chloride concentration or decrease in osmolarity)
- Direct stimulation of a beta 1 receptor
Why is renin released?
Because we want blood pressure to go up
Mascula densa cells are
Are osmo receptors, job is to detect concentrations
3 stages in urine formation
- Glomerular formation
- Tubular reabsorption
- Tubular secretion
2 things in a healthy person that don’t undergo glomerular filtration.
- Cells
2. Proteins
Glucose
Has the ability of increasing concentration in our body, thereby increasing concentration in filtering
Aquaporins
- are special channels, water pores or water channels that allow for water reabsorption, use diuretic hormone
Transport maximum
All of our carrying molecules are saturated, and don’t have any other left. We’ve reached transport maximum
What does angiotension 2 do?
- Very potent ( vasoconstriction)
- Increases sodium reabsorption ( direct & indirect)
- Increases ADH
- Increases thirst
(all increase in blood pressure)
Renal threshold
Glucose we’ve reached transport maximum, is no longer being carried into cell
3 ways to increase osmolarity
- can increase number in solutes, # stuff, particles / amount of fluid
- can decrease amount of fluid
#solutes/ decrease amount of fluids - or both
3 ways to decrease osmolarity
- decrease in solutes/ amount of fluids
- # of solutes/ decrease of fluids
- or both
intrinsic mechanism utilizes what…
osmolarity
solvent is…
always the thing that solutes are dissolved in or held
solvent equals
water
osmolarity is thought out as
stuff in fluid
1 liter of h20
1 kg
fluid is called
solvent
increase in GFR
Increases velocity , decreases amount of tubular reabsorption, increases in osmolarity, increases vasoconstriction (ATP), vasoconstriction @ afferent arterial , decrease in blood flow, decreases GFR
( when GFR went up, the response is going to be opposite)
Decrease in GFR
decreases Velocity , increases tubular reabsorption , decrease in osmolarity , decreases in release of vasoconstriction, decrease in relaxation on AA ( afferent arterial) , increases GFR
(increasing GFR- decrease - to increase GFR: leads to homeostatic response of increasing GFR)
when renin is release it encounters a protein
angiotensinogen and angiotension 1
they are both inactive