FULLY RANDOMIZED PART III Flashcards
Comparing sigmoidoscopy and colonoscopy, which evaluates the descending colon?
Sigmoidoscopy
Comparing psychotherapy, sociotherapy, and pharmacotherapy, which is best to treat antisocial disorder?
Sociotherapy
Which of the pancreatic and biliary system conditions discussed in class are more common in males?
Primary sclerosing cholangitis, chronic pancreatitis, pancreatic cancer (just barely)
What would show in the CSF of a patient with Creutzfeldt-Jakob disease?
14-3-3 protein
An ischemic stroke that is caused by a thrombus can be atherosclerotic or an artery dissection. What are the symptoms of an artery dissection thrombus?
Headache, amaurosis fugax, Horner’s
Comparing angina and myocardial infarction, which is relieved by rest and/or nitroglycerin and is usually of short duration?
Angina
A panic attack by itself is not considered a mental disorder. How does a panic attack specifier differ from a panic attack?
Panic attack specifier is a panic attack in the context of a mental disorder such as PTSD.
Toxocariasis usually doesn’t warrant treatment unless the side effects are severe. What medications could be given then?
VLM: Albendazole, mebendazole, corticosteroids.OLM: corticosteroids, possibly surgery
There are different types of delusional disorder. Briefly describe the persecutory subtype.
Belief that they are being conspired against, cheat, spied on, followed, poisoned/drugged, or obstructed in pursuit of their long time goals.
What techniques are used to diagnose cholecystitis?
Ultrasound, CT.
TST results are made by measuring the induration of the resulting reaction, not the redness. In which individuals would an induration of 10 mm be considered posittive?
Any high risk individual who doesn’t meet the 5mm criteria (health care worker)
How would you treat bacterial meninfitis?
IV vancomyin with ceftriaxone
Define: functional residual capacity.
The volume of air remaining in the lungs at the end of normal expiration.
For women under 65 and adults over 65, what is the number of standard drinks that would indicate an increase in health risks?
7/week, or 3/day
Psychotic disorders are characterized by delusions, hallucinations, disorganized thinking, catatonia, and/or negative symptoms.
Free card.
Emphysema is characterized by the formation of bullae. What are bullae, and how do they form?
They are large spaces where there should be many small alveoli. Repeated and prolonged inflammation causes release of proteolytic enzymes (such as tryptase) that digests the alveolar septal walls.
There are five classes of HIV medications (plus pharmacokinetic enhancers). Describe what entry/fusion inhibitors do, as well as any specific points made during class about this class of medication.
Inhibit fusion with or entry of the virus into the cell. This class is used when other medications have failed.
MG can be exacerbated by medications. Which medications or classes of medications can do this?
Antibiotics (especially gentamycin, tobramycin, telithromycin), fluoroquinolones, hydroxychloroquine, botulinum toxin, penicillamine, beta blockers, anesthetics, and high dose steroids.
The spectrum of schizophrenia has several sub-categories, based on how long they symptoms last. Delusional disorder involves having at least one delusion for how long?
Greater than one month.
_______________ cancer is the 4th leading cause of cancer related deaths among men and women in the US.
Pancreatic
Comparing subdural vs epidural hematomas, which has a slower onset?
Subdural
Gallstones are mostly asymptomatic, although biliary colic sometimes happen. What is biliary colic?
Occurs typically after a fatty meal when the gall bladder contracts and a gallstone blocks the cystic duct. This causes an attack of upper right abdominal pain, N&V, and sometimes pain in the right shoulder/back.
True or false: visceral larva migrans is more common in kids.
True.
How does schizoaffective disorder differ from schizophrenia?
It includes a major mood episode, and the schizophrenia must be uninterrupted.
What visual symptom occurs with a retinal migraine, and how long does it typically last?
Monocular scotoma or blindness*Lasts from minutes to less than an hour
Medications for COPD are pretty similar to asthma. What are a few key differences?
Anticholinergics are FDA approved for COPD (they aren’t for asthma), glucocorticoids are most useful during exacerbations and not as a maintenance med (as with asthma), and aspirin is okay to use because it decreases the platelet count (there is an increased risk of clotting in COPD).
Anticholinergics prevent contraction of airway smooth muscle and are inhaled. Their onset is 3-4 weeks and they are typically less effective than beta 2 agonists.
Free card.
What are the treatment options for choledocholithiasis?
Lithotripsy, cholecystectomy, biliary stenting, ERCP.
What ocular findings might you find in a neonate that would indicate neonatal inclusion conjunctivitis?
Bilateral presentation5-14 days after birthSwelling, hyperemiaChemosis, pseudomembranePapillae, no follicles
Three types of laboratory tests were discussed in class for diagnosis of chlamydia. Which is the historical standard? When would this test be used?
McCoy cell tissue culture. It has high specificity and so is used in court for cases of suspected sexual abuse.
BP above _______________ is considered an emergency.
200/120
What treatments are used for early Lyme disease when the symptoms include meningitis or acute febrile polyneuritis?
IV Ceftriaxone or Penicillin G for 14 days (oral doxy for 28 days if allergic)
Treatment for tension headaches can include analgesics (ibuprofen, naproxen, aspirin) and acetaminophen. Which of these (analgesics vs acetaminophen) is less effective and should be limited in use to 9 days/month and limited to 2 doses/day?
Acetaminophen
Manometry on a patient with scleroderma esophagus would show ___________ (hypotensive/hypertensive) LES and ____________ (poor/strong) peristaltic contraction.
Hypotensive; poor
What do you do if your patient is experiencing diabetic ketoacidosis?
Measure their blood glucose, administer insulin, and keep them hydrated (and correct the electrolyte disturbances), and call 911 or take them to the hospital.
What two conditions qualify as seroconversion, in terms of a TST?
A change from a negative to a positive reaction, or an increase of 10 mm or more in size.
True or false: the only treatment for pancreatic cancer is surgery, but the prognosis is low.
True. The 5-year survival is only 25-30%, and only 15-20% of patients are good candidates for surgery anyway.
True or false: the typical migraine headache lasts less than a day, is uilateral and involves a throbbing or pulsatile pain.
Mostly true–the duration can be anywhere from 4 hours to several days (so not “typically” less than a day)
Comparing psychotherapy, sociotherapy, and pharmacotherapy, which is best to treat schizoid disorder?
Psychotherapy or sociotherapy
What is considered a normal respiratory rate for a child?
up to 20 cycles per minute
What non-surgical treatment options are there for a patient with sleep apnea?
Weight loss, tongue retaining devices, oral mandibular advancement devices, tennis balls on pajamas, anti-inflammatory meds for kids, constant positive airway pressure (CPAP), oropharyngeal exercises.
Name the possible indicators of need for a lumbar puncture, if you are suspicious of neurosyphilis.
Neurological S/S, ophthalmic S/S, HIV infection, failure of treatment, and children with syphilis.
Stress gastritis is caused by a decreased defense mechanism to gastric acid, which can be caused by a reduction in blood flow, mucus, and bicarbonate secretion.
Free card.
Psychotherapy is a general term for the process of treating a condition by talking about it with a mental health provider. There are three specific subdivisions mentioned in class–cognitive behavioral therapy, psychodynamic psychotherapy, and psychoeducation.
Free card.
True or false: toxocara canis completes its life cycle in humans.
False; it stays a larva while in humans.
For acute therapy, treatment should start within how long of the onset of the migraine symptoms?
15 minutes
A CDC diagnosis of AIDs is made whenever a person is HIV+ and ______________ (list all that apply)
CD4 cell count below 200/mm3ORCD4 T-cell % of total lymphocytes below 14%ORDevelopment of an AIDS defining illness (huge list, pneumocystis jirovecii pneumonia is the most common cause of death in AIDS patients)
Comparing cluster headaches and paroxysmal hemicranias, one of them can switch sides between attacks and the other always affects the same side. Which always affects the same side?
Paroxysmal hemicranias
What common medication should be avoided in asthmatics?
Aspirin; it blocks the prostaglandin side of the arachidonic acid metabolism pathway, shunting products toward the leukotriene side. Attacks can be triggered by aspirin (aspirin exacerbated respiratory disease (AERD).
Workup for Zollinger-Ellison Syndrome involves endoscopy (for diagnosis of the ulcer), imaging to locate the gastrinoma, and testing of serum gastrin level. What is considered a normal serum gastrin level?
Less than 100 pg/mL
Describe the treatment for genital chlamydial infections. When would you follow up with the patient to check how treatment went?
Azithromycin 1 g po single dose ORDoxy 100 mg po bid for 1 weekF/U in 3 weeks if pregnant, 3-4 months if not
In what percent of neurologic manifestations of Wilson Disease will the patient also have a Kayser-Fleisher Ring?
98%
How does obesity affect respiration?
The diaphragm and chest wall are mechanically compressed, leading to decreased ventilation of lung bases and hypoxemia, especially when lying down.
What are a few classes of medications used for COPD that are not used for asthma?
Phosphodiesterase inhibitors, aspirin, and antibiotics (due to increased risk of infection).
Asthma can be categorized based on frequency of symptoms, lung function tests (FEV1), and peak flow variability. What are the severity classes of asthma?
Intermittent, mild persistent, moderate persistent, and severe persistent.
In which form of hepatitis are pregnant women more likely to get fulminant hepatic failure, which a higher rate of mortality?
HEV
There are a few different types of syncope: vasovagal, orthostatic, cardiovascular, and cerebrovascular. Which is the most common and due to emotional stress
Vasovagal
What are the symptoms of celiac disease?
Diarrhea, weight loss, fatigue, flatulence, anorexia, abdominal discomfort, and greasy, foul-smelling, voluminous pale stools. The patient may be asymptomatic, however.
Where does copper deposition occur in Wilson disease?
Liver, brain, and cornea
What disease makes up 90% of prion diseases?
Creutzfeldt-Jakob disease
Tranquilizers cause euphoria and sluggishness. Which tranquilizers were asterisked in the presentation?
Benzodiazepines.
What tests are used to diagnose asthma?
Spirometry with postbronchodilator response, pulse oximetry if acute, chest radiograph, and exercise spirometry.
Comparing tension headaches to migraines, which does worsen with exercise?
Migraine
What is the acute treatment for SUNCT?
IV lidocaine
There are five classes of HIV medications (plus pharmacokinetic enhancers). Describe what NNRTIs (non-nukes) do, as well as any specific points made during class about this class of medication.
They attach to and stop reverse transcriptase. Nevirapine is used for infants and pregnant women.
Which is more affected by obstructive pulmonary disease, expiration or inspiration?
Expiration.
What are some of the long term effects of anorexia?
Leukopenia, low bone mineral density, dehydration, dry/yellowish skin, severe constipation, brittle hair/nails, brain damage, internal body temperature drop, infertility.
Name the associated grading scale for the following conditions:TBIMSIIH
TBI: Glasgow coma scaleMS: McDonald criteriaIIH: Modified Dandy criteria
Besides pulmonary and ocular, what other symptoms may a patient cystic fibrosis experience?
Poor digestion of fats (blocked pancreas ducts), poor absorption of proteins and carbs, infertility, cirrhosis, sleep apnea.
The National Dysphagia Diet consists of three levels, numbered 1-3, depending on the severity of the swallowing difficulty. Which level refers to a mild difficulty, in which the patient can still eat most foods but needs them cut into small, bite-sized pieces first?
Level 3
True or false: there is no provent treatment to slow the progression of primary sclerosing cholangitis, though you can do IV fluids and antibiotics for sepsis, and balloon dilation for short term relief. Liver transplant can be used if cirrhosis develops.
True.
Which type of delusional disorder is most common?
Persecutory.
HIV is a retrovirus. What three enzymes does it carry in its capsid? What does each do?
Reverse transcriptase: makes viral DNA from viral RNAIntegrase: pulls viral DNA into cell nucleus and integrates it into host DNAProtease: clips resultant viral protein to form more viral enzymes
Which Cluster C personality disorder is characterized by a difficulty making decisions, a need for others to take charge, a difficulty expressing disagreement, and urgently seeking another relationship for care and support in case the current one ends?
Dependent
What are some of the symptoms of anaphylaxis?
Shakiness, nervousness/anxiety, sweating, chills, clamminess, irritability or impatience, rapid heartbeat, lightheadedness/dizziness, hunger and nausea, sleepiness, headaches, weakness or fatigue, lack of coordination.
Ambulatory pH monitoring, barium swllow, esophageal manometry, and endoscopy are all tests that can be used to evaluate GERD. Which test is used for the detection of complications from GERD?
Endoscopy
Which obstructive pulmonary disease is the most lethal genetic disease affecting Caucasians? What is its inheritance trait?
Cystic fibrosis. It is autosomal recessive, so there are a lot of carriers (1/30 Caucasians).
Fill in the blanks: old hemoglobin is broken down in the ___________, releasing ____________ (unconjugated/conjugated) bilirubin, which is transported by _____________ to the _____________, where it is converted to ________________ (unconjugated/conjugated) bilirubin and exceted into the bile.
Old hemoglobin is broken down in the spleen, releasing unconjugated bilirubin, which is transported by albumin to the liver, where it is converted to conjugated bilirubin and exceted into the bile.
Comparing tension headaches to migraines, which does not worsen with exercise?
Tension
List the treatment options for acute pancreatitis.
Pain control, IV fluids, ICU (if severe), pancreatic debridement (if necrosis), and treatment of the underlying cause.
What is the most common trigger for a tension headache?
Stress*
Cluster headache attacks typically occur 1-3 times daily. How quickly do they onset, and how long do they typically last?
Onset is rapid (5 minutes)*, and duration is between 15 minutes to 3 hours
True or false: though there is no treatment for Creutzfeldt-Jakob disease, patients usually live for 5 years after diagnosis.
False; patients live for about 6 months (and there is no treatment)
The cortical spreading depression (CSD) theory of migraine pathophysiology states that aura are caused by a wave of excitation in parts of the brain. CSD is also said to activate trigeminal
Calcitonin gene-related peptide (CGRP)*, substance P, neurokinin A
ABCDD is an acronym used to estimate the risk of a stroke in the first two days after a transient ischemic attack. What do these letters stand for?
Age (over 60)Blood pressure after TIA (over 140 systolic OR over 90 diastolic)Clinical features (unilateral weakness, speech disturbance)DurationDiabetes
What sort of workup can be done for a patient who has had a transient ischemic attack?
MRI (with diffusion weighted imaging), CT, MRA, CTA, ECG, CBC, metabolic panel, coagulation screening, lipid profile, ESR, CRP, Doppler and carotid Doppler
What effect does the sympathetic nervous system have on the lungs?
Very mild arteriolar constriction, bronchial smooth muscle dilation, and inhibition of mucous glands.
Which of the stomach/intestine conditions discussed in class has a higher prevalence in men?
Gastric cancer, Zollinger-Ellison Syndrome, colorectal cancer, and peptic ulcer disease (though just barely)
Briefly outline the disease process of histoplasmosis.
Spores are inhaled and fungi proliferate in the lungs. PMNs and macrophages infiltrate the lungs and phagocytotize the fungi but don’t kill it. They carry it throughout the body. An immune resopnse develops, leading to granuloma formation, necrosis, and fibrotic encapsulation, which can later calcify (histoplasmoma).
The incubation period for chlamydia is around 7-21 days. How is the disease transmitted? What is the co-infection rate?
Transmitted by direct contact with urine or genital secretions. 50% co-infection rate
What are the most common adverse effects of glucocorticoids? Which of these effects are less likely with inhaled glucocorticoids?
Osteoporosis, impaired wound healing, increased risk of infection, HTN, edema, ulcers, psychoses, Cushing-like syndrome, oral candidiasis. Decreased growth in children, glaucoma, cataracts, and increased risk of DM are less likely in inhaled vs. oral glucocorticoids.
What are the roles of the pulmonary system?
Acquire O2, get rid of CO2, and provide fast adjustment to blood pH.
IBS has between 50% and 70% comorbidity with psychiatric disorders, chronic pelvic pain, temporomandibular joint disorder, and chronic fatigue sydrome, and 20-50% with fibromyalgia.
Free card.
Cluster headaches feature excruciating unilateral orbital or temporal pain, accompanied by autonomic symptoms. Its overall prevalence is less than 1%. What percetage of patients experience autonomic symptoms? What sorts of autonomic symptoms are they?
97%*; parasympathetic symptoms such as lacrimation, injection, ptosis, miosis, etc.
There are a few different forms of multiple sclerosis: clinically isolated syndrome (CIS), relapsing-remissing (RRMS), secondary-progressive (SPMS), and primary progressive (PPMS). Which form has a later age of onset and has a worse prognosis?
PPMS
True or false: ethosuximide and gabapentin are both acceptable drugs for absence seizures
False; only ethosuximide; gabapentin is contraindicated.
Comparing angina and myocardial infarction, which is not relieved by rest or nitroglycerin and can last hours?
Myocardial infarction.
What are some of the acute treatment options for cluster headaches?
100% oxygen therapy, subcutaneous or nasal sumatriptan
The most common type of aura is visual. It occurs over 5 minutes and may be a zig-zag pattern or a shimmering scintillating appearance. It may be a C-shape and will leavea a central scotoma
Free card.
True or false: eradication of H. Pylori decreases ulcer recurrence to less than 10%
True.
Leukotriene inhibitors are not used for immediate bronchodilation and are taken orally. Their most concerning side effect is impact on liver function, though they can cause HA, fever, sore throat, sinus infection, and SJS.
Free card.
What are the symptoms of scleroderma?
Dysphagia, dry mouth, calcific skin deposits, tight skin, severe GERD, and chest pain.
There are neurologic, iatrogenic, structural, muscular, infectious, and metabolic causes of oropharyngeal dysphagia. What structural causes are possible?
Neoplasia, Zenker’s diverticulum, cricopharyngeal bar
______________________ is chronic inflammation, fibrosis, and stricturing of the biliary tree inside and/or outside of the liver.
Primary sclerosing cholangitis.
Transient ischemic attacks involve no infarction (tissue death) and there is full recovery of function. How long does a TIA usually last?
About 1 minute, but possible up to under 24 hours.
What sort of lab tests could you run on a patient with scleroderma?
ANA, anti-scl-70, anticentromere antibodies
Inhaled glucocorticoids should be used with caution in patients with what conditions?
Parasitic infection, active or inactive TB, ocular herpes simplex, or increased IOP.
True or false: about 2/3 of IBS patients experience decreased pain sensitivity in gut stimulation.
False; 2/3 have increased pain sensitivity in gut stimulation
Which of the stomach/intestine conditions discussed in class has a higher prevalence in women?
Celiac disease and irritable bowel syndrome
10-35% of heavy drinkers have ___________.
Alcoholic hepatitis (aka alcoholic steatohepatitis), inflammation of a fatty liver
In terms of classifying the severity of bulimia, how many episodes per week is considered extreme?
Fourteen or more
The diagnostic criteria for a migraine without aura includes the headache lasting how long?
4 to 72 hours
If the early/localized form of Lyme disease is untreated, early disseminated infection can develop days to weeks after the bite. This stage can include more erythema migrans as well as the following three categories of symptoms:-Rheumatoid-Neurological-CardiacWhat percentage of patients in the early disseminated form experience each of these categories? What specific symptoms occur in these stages?
Rheumatoid = 30%-arthalgia with swellingNeurological (15%)-CN palsies (especially Bell’s palsy with a fever)-meningitis-acute febrile polyneuritisCardiac (1%)-myopericarditis-AV conduction defects or tachyarrythmias
Which class of medication is first option when treating moderate to severe asthma?
Inhaled glucocorticoids, due to their ability to decrease remodeling. They can be either aerosol or powdered.
Which patients with histoplasmosis may find themselves on anti-fungals for life?
Immunosuppressed
In order for chronic bronchitis to be diagnosed, what must a patient have experienced?
Persistent, productive cough on most days for at least 3 consecutive months in two consecutive years.
What is the treatment for chronic pancreatitis?
Pain management, lifestyle changes (smaller meals, low-fat meals, no alcohol or tobacco), pancreatic lithotripsy, surgery.
Nearly 90% of headaches fall into one of these categories: migraine, tension-type, chronic daily, and cluster. Which of these types of the most commonly diagnosed?
Migraine
Which Cluster B personality disorder is characterized by shifts between idealization and devaluation (“splitting”)?
Borderline