FTM 1 Exam 1 Drugs Flashcards
What prevents microtubule disassembly and what category of drug is it?
Taxol
-anti-cancer
What Prevents microtubule assembly (polymerization) fights inflammation and what category of drug is it?
Colchicine
-anti-gout, anti-cancer
What presents microtubule assembly and what category of drug is it?
Vincristine/vinblastine
-anti-cancer
What disrupts actin function–> no cell movement and what category of drug is it?
Phalloidin and Cytochalasin
-Toxin
What inhibits DNA gyrase and What disrupts actin function–> no cell movement and what category of drug is it?
Ciproflaxin (antibiotic respiratory infection)
Novabiocin (antibiotic staph infection, MRSA)
Nalidixic Acid (Antibiotic respiratory infection and UTI)
What disrupts DNA elongation —> base lacks 3’ OH and what category of drug is it?
Azidothymidine (AZT) Zidovudine -anti-viral Didanosine (ddl) -anti-viral Acylovir -anti-viral (herpes)
What disrupts DNA elongation –> competes w/ dATP and what category of drug is it?
Tenofovir
-anti-viral
What has 3’ OH = stereo restraint —> chain termination and what category of drug is it?
Adenine Arabinoside (araA)
-anti-viral
Cytosine arabinoside (araC)
-anti-cancer
What binds and inhibits topoisomerase I and what category of drug is it?
Camptothecin
-anti-cancer
What inhibits topoisomerase II and what category of drug is it?
Etoposide
-anti-cancer
What inhibits RNA polymerization on both prokaryotes and eukaryotes and what category of drug is it?
Actinomycin D
-anti-cancer
What inhibits RNA polymerase –> inhibit initiation of transcription and what category of drug is it?
Rifampin
-antibiotic
What inhibits RNA polymerase II —> hepatotoxicity–> death and what category of drug is it?
alpha-amanitin (mushroom)
-toxin
What inhibits RNA polymerase II –> not absorbed by the GI tract –> not toxic by oral intake and what category of drug is it?
Phalloidin
-toxin
What blocks initiation and prevents assembly of ribosomes by binding to 30s and what category of drug is it?
Streptomycin
-abx
What blocks elongation and prevents aminoacyl-tRNA access to A site and what category of drug is it?
Tetracycline
-abx
What blocks elongation and blocks ribosomes translocation by binding to 50s and what category of drug is it?
Erythromycin
-abx
What blocks elongation and prevents peptidyl transferase activity in prokaryotes and what category of drug is it?
Chloramphenicol
-abx
What blocks elongation and prevents peptidyl transferase activity in eukaryotes and what category of drug is it?
Cycloheximide
-abx
(not really used in humans)
What blocks elongation and premature termination in translation by bearing structural resemblance to aminoacyl-tRNA and what category of drug is it?
Puromycin
-abx
(not really used in humans)
What inactivated EF-2 –> prevent translocation and what category of drug is it?
Diphtheria toxin
-toxin
What inhibits conversion of IMP to GMP and what category of drug is it?
Mycophenolic acid
-immunosuppressive
What inhibits folate synthesis and what category of drug is it?
sulfonamide/sulfa drugs
-abx
What inhibits bacterial dihydrofolate and what category of drug is it?
Trimethoprim
-abx
What inhibits eukaryotic dihydrofolate reductase and what category of drug is it?
Methotrexate
-anti-cancer
What inhibits ribonucleotide reductase and what category of drug is it?
hydroxyurea
-anti-cancer
What inhibits xanthine oxidase and what category of drug is it?
allopurinol
-anti-gout
What inhibits thidiylate synthase and what category of drug is it?
5’ Fluorouracil
-anti-cancer
