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shared cards > FTM-1 drugs > Flashcards

FTM-1 drugs Flashcards

1
Q

AZT/zidovudine

A
  • viral reverse transcriptase inhibitor; inhibits viral replication
  • treats HIV
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2
Q

diadenosine

A
  • viral reverse transcriptase inhibitor; inhibits viral replication
  • treats HIV
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3
Q

tenofovir

A
  • viral reverse transcriptase inhibitor; inhibits viral replication
  • treats HIV
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4
Q

acyclovir

A
  • viral DNA polymerase inhibitor; inhibits viral replication

- treats herpes simplex, varicella & zoster

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5
Q

araC/cytarabine

A
  • causes DNA damage due to steric hindrance; inhibits DNA replication & human DNA polymerase
  • treats cancer
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6
Q

araA/vidarabine

A
  • inhibits viral DNA polymerase

- treats cancer

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7
Q

decitabine

A
  • upregulates transcription of tumor suppressor gene

- treats cancer

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8
Q

ciprofloxacin

A
  • DNA gyrase inhibitor; disrupts DNA replication & transcription
  • treats anthrax, UTI’s & respiratory infections
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9
Q

novobiocin

A
  • DNA gyrase inhibitor; disrupts DNA replication & transcription
  • treats staph/MRSA infections
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10
Q

camptothecin

A
  • inhibits eukaryotic topoisomerase I

- treats cancer

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11
Q

etoposide

A
  • inhibits eukaryotic topoisomerase II

- treats cancer

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12
Q

actinomycin D

A
  • inhibits DNA replication & transcription

- treats cancer

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13
Q

rifampin

A
  • inhibits prokaryotic RNA polymerase

- treats TB

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14
Q

diptheria toxin

A
  • inhibits protein synthesis

- toxin; not a treatment

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15
Q

streptomycin

A
  • binds prokaryotic 30S ribosomal subunits

- treats bacterial infections

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16
Q

tetracycline

A
  • binds prokaryotic 30S subunit of complete 70S ribosomal subunit
  • treats bacterial infections
17
Q

erythromycin

A
  • binds prokaryotic 50S subunit of complete 70S ribosomal subunit
  • treats bacterial infections
18
Q

chloramphenicol

A
  • inhibits prokaryotic peptidyltransferase/”charging” of tRNA
  • treats bacterial infections
19
Q

cycloheximide

A
  • inhibits eukaryotic peptidyltransferase/”charging” of tRNA

- treats bacterial infections

20
Q

puromycin

A
  • inhibits eukaryotic peptidyltransferase/”charging” of tRNA

- treats bacterial infections

21
Q

alpha-amantin toxin (death cap mushroom)

A
  • inhibits eukaryotic RNA pol II

- treatment: penicillin, GI decontamination, liver transplant

22
Q

colchicine

A
  • prevents tubulin polymerization/cellular division

- treats cancer

23
Q

taxol

A
  • inhibits metaphase/cellular division

- treats cancer

24
Q

phalloidin (death cap mushroom)

A
  • disrupts normal functions of actin/inhibits cell movement

- causes liver & kidney failure; death 4-8 days after consumption

25
Q

cytyochalasins

A
  • blocks actin polymerization; inhibits cell movement/division
26
Q

statin drugs

A
  • competitive reversible inhibitor of HMG CoA reductase

- prevents cholesterol synthesis

27
Q

DFP

A
  • irreversible inhibitor of acetylcholinesterase
  • causes continuous stimulation of muscle contraction/overstimulation of ANS, blurred vision, bronchoconstriction, seizures, respiratory arrest & death
28
Q

aspirin

A
  • irreversibly competitively inhibits COX 1&2

- treats pain; thins blood

29
Q

allopurinol

A
  • irreversibly inhibits xanthine oxidase

- treats gout/overproduction of uric acid

30
Q

sulfonamides

A
  • competitively inhibits formyltransferases

- treats bacterial infections

31
Q

methotrexate

A
  • competitively inhibits dihydrofolate reductase

- treats cancer, psoriasis, rheumatoid arthritis & neoplastic diseases

32
Q

trimethoprim

A
  • inhibits prokaryotic dihydrofolate reductase

- promotes tetrahydrofolic acid (important in amino acid synthesis)

33
Q

mycophenolic acid

A
  • reversible non-competitive inhibitor of inosine monophosphate dehydrogenase
  • prevents graft rejection
34
Q

hydroxyurea

A
  • inhibits ribonucleotide diphosphate reductase

- treats cancer

35
Q

EFFUDEX

A
  • competitively inhibits thymidylate synthase

- treats cancer

36
Q

caffeine

A
  • inhibits phosphodiesterase

- cAMP not properly degraded

37
Q

theophylline

A
  • inhibits phosphodiesterase

- cAMP not properly degraded

38
Q

cholera/E. coli toxin

A
  • cAMP continuously synthesized

- causes diarrhea

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