FTM-1 drugs Flashcards
1
Q
AZT/zidovudine
A
- viral reverse transcriptase inhibitor; inhibits viral replication
- treats HIV
2
Q
diadenosine
A
- viral reverse transcriptase inhibitor; inhibits viral replication
- treats HIV
3
Q
tenofovir
A
- viral reverse transcriptase inhibitor; inhibits viral replication
- treats HIV
4
Q
acyclovir
A
- viral DNA polymerase inhibitor; inhibits viral replication
- treats herpes simplex, varicella & zoster
5
Q
araC/cytarabine
A
- causes DNA damage due to steric hindrance; inhibits DNA replication & human DNA polymerase
- treats cancer
6
Q
araA/vidarabine
A
- inhibits viral DNA polymerase
- treats cancer
7
Q
decitabine
A
- upregulates transcription of tumor suppressor gene
- treats cancer
8
Q
ciprofloxacin
A
- DNA gyrase inhibitor; disrupts DNA replication & transcription
- treats anthrax, UTI’s & respiratory infections
9
Q
novobiocin
A
- DNA gyrase inhibitor; disrupts DNA replication & transcription
- treats staph/MRSA infections
10
Q
camptothecin
A
- inhibits eukaryotic topoisomerase I
- treats cancer
11
Q
etoposide
A
- inhibits eukaryotic topoisomerase II
- treats cancer
12
Q
actinomycin D
A
- inhibits DNA replication & transcription
- treats cancer
13
Q
rifampin
A
- inhibits prokaryotic RNA polymerase
- treats TB
14
Q
diptheria toxin
A
- inhibits protein synthesis
- toxin; not a treatment
15
Q
streptomycin
A
- binds prokaryotic 30S ribosomal subunits
- treats bacterial infections
16
Q
tetracycline
A
- binds prokaryotic 30S subunit of complete 70S ribosomal subunit
- treats bacterial infections
17
Q
erythromycin
A
- binds prokaryotic 50S subunit of complete 70S ribosomal subunit
- treats bacterial infections
18
Q
chloramphenicol
A
- inhibits prokaryotic peptidyltransferase/”charging” of tRNA
- treats bacterial infections
19
Q
cycloheximide
A
- inhibits eukaryotic peptidyltransferase/”charging” of tRNA
- treats bacterial infections
20
Q
puromycin
A
- inhibits eukaryotic peptidyltransferase/”charging” of tRNA
- treats bacterial infections
21
Q
alpha-amantin toxin (death cap mushroom)
A
- inhibits eukaryotic RNA pol II
- treatment: penicillin, GI decontamination, liver transplant
22
Q
colchicine
A
- prevents tubulin polymerization/cellular division
- treats cancer
23
Q
taxol
A
- inhibits metaphase/cellular division
- treats cancer
24
Q
phalloidin (death cap mushroom)
A
- disrupts normal functions of actin/inhibits cell movement
- causes liver & kidney failure; death 4-8 days after consumption
25
cytyochalasins
- blocks actin polymerization; inhibits cell movement/division
26
statin drugs
- competitive reversible inhibitor of HMG CoA reductase
| - prevents cholesterol synthesis
27
DFP
- irreversible inhibitor of acetylcholinesterase
- causes continuous stimulation of muscle contraction/overstimulation of ANS, blurred vision, bronchoconstriction, seizures, respiratory arrest & death
28
aspirin
- irreversibly competitively inhibits COX 1&2
| - treats pain; thins blood
29
allopurinol
- irreversibly inhibits xanthine oxidase
| - treats gout/overproduction of uric acid
30
sulfonamides
- competitively inhibits formyltransferases
| - treats bacterial infections
31
methotrexate
- competitively inhibits dihydrofolate reductase
| - treats cancer, psoriasis, rheumatoid arthritis & neoplastic diseases
32
trimethoprim
- inhibits prokaryotic dihydrofolate reductase
| - promotes tetrahydrofolic acid (important in amino acid synthesis)
33
mycophenolic acid
- reversible non-competitive inhibitor of inosine monophosphate dehydrogenase
- prevents graft rejection
34
hydroxyurea
- inhibits ribonucleotide diphosphate reductase
| - treats cancer
35
EFFUDEX
- competitively inhibits thymidylate synthase
| - treats cancer
36
caffeine
- inhibits phosphodiesterase
| - cAMP not properly degraded
37
theophylline
- inhibits phosphodiesterase
| - cAMP not properly degraded
38
cholera/E. coli toxin
- cAMP continuously synthesized
| - causes diarrhea
