FRS Pharmacology Estrogen Receptor Modulators

Question 1

Estrogen Receptor Modulators

Answer 1

• Raloxifine- used to create positive effect on estrogen replacement
• Current Forms:
  Raloxifine (Evista)- used to prevent or treat osteoporosis; menopausal osteoporosis
  Toremifene (fareston) - Used as antineoplatic agent effect on estrogen receptor site

Question 2

Estrogen Receptor Modulators Pharmacokinetics

Answer 2

• Raloxifene- Well absorbed from GIT; metabolized in liever; excreted in feces; crosses placenta and enter breast milk
• Don’t use while pregnant and lactating
• Oral
• Onset varies
• Peak- 4 to 7 hours
• Duration 24 hrs
• T1/2 27.7 hrs

Question 3

Estrogen Receptor Modulators Contraindication and Caution

Answer 3

• Raloxifene- any known allergies
• pregnancy or lactation
• hostory of venous thrombosis or smoking
• increased risk of bloodclot formation

Question 4

Estrogen Receptor Modulators Drug to Drug Interaction

Answer 4

• Cholestyramine- reduce absorption of raloxifene
• Highly protien bound drugs may interfere with binding sites - Diazepam, ibuprofen, indomethasin (indosin), naproxen (naprosyn)
• Warfarin- raloxifene may decrease prothrombin time of warfarin (mointor pt closely)

Question 5

Estrogen Receptor Modulators Adverse Effects

Answer 5

• nausea, vomiting, lightheadedness, depression, hot flashes, skin rash, vaginal bleeding, venous thromboembolism

Question 6

Estrogen Receptor Modulators Nursing Implications

Answer 6

• Administer drugs as prescribed to prevent adverse effect
• Administer with food if GIT upset is severe
• Provide analgesics for headache as needed
• Monitor liver function periodically for pt on long term therapy
• Provide support and reassurance to deal with drug to drug effects
• Provide thorough pt knowledge