From Lezak Ch. 7

Question 1

What prop. Of adults in U.S. Will develop a brain tumor in a given year? Which is roughly how many new cases?

Answer 1

46 out of every 100,000

115,000 new U.S. Cases

Question 2

In adults, most brain tumors are primary or secondary?

Answer 2

Secondary metastases 2:1

Opposite is true for children

Question 3

What is another term for Brain metastasis

Answer 3

Secondary intracranial neoplasm

Question 4

What factors impact the specific cognitive and neurobiological behavioral effects of the brain tumor

Answer 4

Nature, site, size, rate of growth, treatments

Question 5

Define Glioma

Answer 5

Tumors that arise from the glial cells forming the connective tissues of the brain

Question 6

What is the most common primary brain tumor in adults

Answer 6

Glioma

Question 7

Gliomas account for what proportion of all brain tumors

Answer 7

Approximately half

Question 8

Are gliomas more common in men or women?

Answer 8

Men 1.6:1

Question 9

Gliomas can be further subdivided into:

Answer 9

Astrocytomas, oligodendroglial tumors, and mixed gliomas

Question 10

Brain tumors are graded according to?

Answer 10

The most malignant area within them

Question 11

What is the most common kind of Glial tumor in an adult

Answer 11

Malignant astrocytic tumors i.e. glioblastoma multiforme and anaplastic astrocytoma

Question 12

Glioblastoma’s constitute what what proportion of malignant gliomas

Answer 12

80%

Question 13

Glioblastoma is typically present in which decade of life

Answer 13

The sixth or seventh decade

Question 14

Astrocytomas typically present in which decayed of life?

Answer 14

Fourth or fifth

Question 15

Is surgical resection of glioblastoma multi-form for anaplastic astrocytoma possible? Why or why not

Answer 15

Surgical resection is nearly impossible because the tumor has invaded the surrounding neural tissue

Question 16

Astrocytic tumors are easily identified on MRI by:

Answer 16

There irregular ring-like gadolinium. Enhancement, surrounding edema, and mass effect

Question 17

Because you can really resect the entire tumor what does treatment for astrocytic gliomas involve

Answer 17

So divorce action of as much as the tumors possible, cranial radiation, possibly the addition of chemotherapy although this has produced only modest increases in survival times

Question 18

Median survival time for glioblastoma patients

Answer 18

One year from diagnosis

Question 19

Median survival time for patients with anaplastic astrocytoma’s

Answer 19

Two years from diagnosis

Question 20

Lower grade astrocytoma tend to occur in what decade of life

Answer 20

Second or third

Question 21

The first sign of a low-grade astrocytoma is generally what? Until then they are generally what

Answer 21

Seizure; neurologically intact

Question 22

On MRI low grade astrocytomas appear as:

Answer 22

Text use non-enhancing masses without surrounding edema or mass effect

Question 23

On PET scanning low-grade astrocytomas are,

Answer 23

Hypometabolic… Hyper metabolic areas would suggest a more malignant process

Question 24

Treatment of low-grade astrocytomas

Answer 24

Subject of some debate, maybe delayed until symptoms of merge or condition worsens, complete surgical removal is ideal but may not be possible, chemotherapy is of limited benefit, post surgical radiation therapy is often recommend

Question 25

What kind of postsurgical radiation therapy is often recommended for low-grade astrocytoma patients

Answer 25

Low-dose radiation therapy, which is which is as efficacious as higher doses that with fewer side effects

Question 26

Prognosis associated with low-grade astrocytomas

Answer 26

Most will involve an into malignant gliomas, median survival time for patients is approximately five years but there’s considerable vera Bill variability,

Question 27

What factors are associated with poor prognosis for low-grade astrocytomas

Answer 27

Age over 40, larger tumor size, tumor crosses the midline, and the presence of neurological deficits prior to surgery

Question 28

Oligodendrogliomas account for what percentage of Glial neoplasms

Answer 28

20%

Question 29

Oligodendrogliomas, more common in men or women?

Answer 29

Men 2:1

Question 30

Oligodendrogliomas typically occur in what day decade of life

Answer 30

Second or third

Question 31

Oligodendrogliomas typically arise from what part of the brain

Answer 31

The deep white matter underlying the frontal or Temporel lobe

Question 32

What are often the first signs of an oligodendroglioma

Answer 32

Seizure, headache, progressive hemiparesis

Question 33

In the case of oligodendroglioma’s, is hemiparesis always progressive?

Answer 33

No, it can be a cute in on said if there has been a hemorrhage

Question 34

Treatment for Oligodendrogliomas

Answer 34

Surgical resection if possible, chemotherapy and postsurgical radiation… These tumors are unusually sensitive to chemotherapy, unlike astrocytomas

Question 35

Oligodendroglioma prognosis

Answer 35

75% respond to chemotherapy, nearly half of these people can function at premorbid levels or at least have sustained remission with meaningful clinical improvement

Question 36

Hat proportion of ca pts will develop tumors that invade or impinge on brain tissue?

Answer 36

1 in 4